Search Results
Overview
| Uniprot ID | Q8N5I9 |
|---|---|
| Protein Name | NOP protein chaperone 1 |
| Gene Name | NOPCHAP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 182 | VLDSPASKKKK**** |
| 183 | LDSPASKKKK***** |
| 51 | LLINSQPKSRKTSTL |
Function
Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2
Protein Sequence
10
MEVHGKPKAS
20
PSCSSPTRDS
30
SGVPVSKELL
40
TAGSDGRGGI
50
WDRLLINSQP
60
KSRKTSTLQT
70
VRIERSPLLD
80
QVQTFLPQMA
90
RANEKLRKEM
100
AAAPPGRFNI
110
ENIDGPHSKV
120
IQMDVALFEM
130
NQSDSKEVDS
140
SEESSQDSSE
150
NSSESEDEDD
160
SIPSEVTIDN
170
IKLPNSEGGK
180
GKIEVLDSPA
SKKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0062064 | box C/D methylation guide snoRNP complex binding |
| Biological Process | GO:0000492 | box C/D snoRNP assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.