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Overview

Uniprot IDQ8N5P1
Protein NameZinc finger CCCH domain-containing protein 8
Gene NameZC3H8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 TPQAAKQKNKNLKAG
147 KQKKMKRKWPGPGNK
175 EDGKPKEKQQHLSQA
51 LECEQIPKKFRHSAI
52 ECEQIPKKFRHSAIS
61 RHSAISPKSSLHRKS

Function

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis

Protein Sequence

10 MDFENLFSKP 20 PNPALGKTAT 30 DSDERIDDEI 40 DTEVEETQEE 50 KIKLECEQIP 60 KKFRHSAISP 70 KSSLHRKSRS 80 KDYDVYSDND 90 ICSQESEDNF 100 AKELQQYIQA 110 REMANAAQPE 120 ESTKKEGVKD 130 TPQAAKQKNK 140 NLKAGHKNGK 150 QKKMKRKWPG 160 PGNKGSNALL 170 RNSGSQEEDG 180 KPKEKQQHLS 190 QAFINQHTVE 200 RKGKQICKYF 210 LERKCIKGDQ 220 CKFDHDAEIE 230 KKKEMCKFYV 240 QGYCTRGENC 250 LYLHNEYPCK 260 FYHTGTKCYQ 270 GEYCKFSHAP 280 LTPETQELLA 290 KVLDTEKKSC K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0035363 histone locus body
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0008023 transcription elongation factor complex
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0032785 negative regulation of DNA-templated transcription, elongation
Biological Process GO:0033085 negative regulation of T cell differentiation in thymus
Biological Process GO:1905382 positive regulation of snRNA transcription by RNA polymerase II
Biological Process GO:0070245 positive regulation of thymocyte apoptotic process
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:0046677 response to antibiotic
Biological Process GO:0042795 snRNA transcription by RNA polymerase II
Biological Process GO:0042796 snRNA transcription by RNA polymerase III
Biological Process GO:0043029 T cell homeostasis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.