Overview
| Uniprot ID | Q8N5Y2 |
|---|
| Protein Name | MSL complex subunit 3 |
|---|
| Gene Name | MSL3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 339 |
PATPKRRKAEPEALQ |
Function
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699)
Protein Sequence
10
MSASEGMKFK
20
FHSGEKVLCF
30
EPDPTKARVL
40
YDAKIVDVIV
50
GKDEKGRKIP
60
EYLIHFNGWN
70
RSWDRWAAED
80
HVLRDTDENR
90
RLQRKLARKA
100
VARLRSTGRK
110
KKRCRLPGVD
120
SVLKGLPTEE
130
KDENDENSLS
140
SSSDCSENKD
150
EEISEESDIE
160
EKTEVKEEPE
170
LQTRREMEER
180
TITIEIPEVL
190
KKQLEDDCYY
200
INRRKRLVKL
210
PCQTNIITIL
220
ESYVKHFAIN
230
AAFSANERPR
240
HHHVMPHANM
250
NVHYIPAEKN
260
VDLCKEMVDG
270
LRITFDYTLP
280
LVLLYPYEQA
290
QYKKVTSSKF
300
FLPIKESATS
310
TNRSQEELSP
320
SPPLLNPSTP
330
QSTESQPTTG
340
EPATPKRRKA
350
EPEALQSLRR
360
STRHSANCDR
370
LSESSASPQP
380
KRRQQDTSAS
390
MPKLFLHLEK
400
KTPVHSRSSS
410
PIPLTPSKEG
420
SAVFAGFEGR
430
RTNEINEVLS
440
WKLVPDNYPP
450
GDQPPPPSYI
460
YGAQHLLRLF
470
VKLPEILGKM
480
SFSEKNLKAL
490
LKHFDLFLRF
500
LAEYHDDFFP
510
ESAYVAACEA
520
HYSTKNPRAI
Y
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0072487 |
MSL complex |
| Cellular Component |
GO:0035267 |
NuA4 histone acetyltransferase complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0140046 |
histone H4K16ac reader activity |
| Molecular Function |
GO:0140566 |
histone reader activity |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.