Search Results

Overview

Uniprot IDQ8N5Z0
Protein NameKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Gene NameAADAT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
188 EDAKNPQKNTPKFLY
263 IRADSFSKIISSGLR

Function

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)

Protein Sequence

10 MNYARFITAA 20 SAARNPSPIR 30 TMTDILSRGP 40 KSMISLAGGL 50 PNPNMFPFKT 60 AVITVENGKT 70 IQFGEEMMKR 80 ALQYSPSAGI 90 PELLSWLKQL 100 QIKLHNPPTI 110 HYPPSQGQMD 120 LCVTSGSQQG 130 LCKVFEMIIN 140 PGDNVLLDEP 150 AYSGTLQSLH 160 PLGCNIINVA 170 SDESGIVPDS 180 LRDILSRWKP 190 EDAKNPQKNT 200 PKFLYTVPNG 210 NNPTGNSLTS 220 ERKKEIYELA 230 RKYDFLIIED 240 DPYYFLQFNK 250 FRVPTFLSMD 260 VDGRVIRADS 270 FSKIISSGLR 280 IGFLTGPKPL 290 IERVILHIQV 300 STLHPSTFNQ 310 LMISQLLHEW 320 GEEGFMAHVD 330 RVIDFYSNQK 340 DAILAAADKW 350 LTGLAEWHVP 360 AAGMFLWIKV 370 KGINDVKELI 380 EEKAVKMGVL 390 MLPGNAFYVD 400 SSAPSPYLRA 410 SFSSASPEQM 420 DVAFQVLAQL IKESL

Gene Ontology

Classification GO ID Description
Molecular Function GO:0016212 kynurenine-oxoglutarate transaminase activity
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0047536 2-aminoadipate transaminase activity
Molecular Function GO:0047958 glycine:2-oxoglutarate aminotransferase activity
Molecular Function GO:0047315 kynurenine-glyoxylate transaminase activity
Molecular Function GO:0050094 methionine-glyoxylate transaminase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:1901605 alpha-amino acid metabolic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0070189 kynurenine metabolic process
Biological Process GO:0033512 L-lysine catabolic process to acetyl-CoA via L-saccharopine

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.