Search Results

Overview

Uniprot IDQ8N6T3
Protein NameADP-ribosylation factor GTPase-activating protein 1
Gene NameARFGAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
114 AAALFRDKVVALAEG
194 GNTPPPQKKEDDFLN
195 NTPPPQKKEDDFLNN
226 SRFASAAKEGATKFG
231 AAKEGATKFGSQASQ
278 GVSQLASKVQGVGSK
285 KVQGVGSKGWRDVTT
342 AEPTKTRKSPSSDSW

Function

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity)

Protein Sequence

10 MASPRTRKVL 20 KEVRVQDENN 30 VCFECGAFNP 40 QWVSVTYGIW 50 ICLECSGRHR 60 GLGVHLSFVR 70 SVTMDKWKDI 80 ELEKMKAGGN 90 AKFREFLESQ 100 EDYDPCWSLQ 110 EKYNSRAAAL 120 FRDKVVALAE 130 GREWSLESSP 140 AQNWTPPQPR 150 TLPSMVHRVS 160 GQPQSVTASS 170 DKAFEDWLND 180 DLGSYQGAQG 190 NRYVGFGNTP 200 PPQKKEDDFL 210 NNAMSSLYSG 220 WSSFTTGASR 230 FASAAKEGAT 240 KFGSQASQKA 250 SELGHSLNEN 260 VLKPAQEKVK 270 EGKIFDDVSS 280 GVSQLASKVQ 290 GVGSKGWRDV 300 TTFFSGKAEG 310 PLDSPSEGHS 320 YQNSGLDHFQ 330 NSNIDQSFWE 340 TFGSAEPTKT 350 RKSPSSDSWT 360 CADTSTERRS 370 SDSWEVWGSA 380 STNRNSNSDG 390 GEGGEGTKKA 400 VPPAVPTDDG WDNQNW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0015031 protein transport
Biological Process GO:0032012 regulation of ARF protein signal transduction
Biological Process GO:0030100 regulation of endocytosis
Biological Process GO:0016192 vesicle-mediated transport
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0005096 GTPase activator activity

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.