Search Results
Overview
| Uniprot ID | Q8N7B1 |
|---|---|
| Protein Name | HORMA domain-containing protein 2 |
| Gene Name | HORMAD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 76 | KILREDKKCPGSLHI |
Function
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity)
Protein Sequence
10
MATAQLSHCI
20
TIHKASKETV
30
FPSQITNEHE
40
SLKMVKKLFA
50
TSISCITYLR
60
GLFPESSYGE
70
RHLDDLSLKI
80
LREDKKCPGS
90
LHIIRWIQGC
100
FDALEKRYLR
110
MAVLTLYTDP
120
MGSEKVTEMY
130
QFKFKYTKEG
140
ATMDFDSHSS
150
STSFESGTNN
160
EDIKKASVLL
170
IRKLYILMQD
180
LEPLPNNVVL
190
TMKLHYYNAV
200
TPHDYQPLGF
210
KEGVNSHFLL
220
FDKEPINVQV
230
GFVSTGFHSM
240
KVKVMTEATK
250
VIDLENNLFR
260
ENSTTEIAHQ
270
GLDCDEEEEC
280
NDHIQRMNFV
290
CSQQSSECSR
300
KKRKVSEPVK
VFIPNRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000795 | synaptonemal complex |
| Biological Process | GO:0051321 | meiotic cell cycle |
| Biological Process | GO:0051598 | meiotic recombination checkpoint signaling |
| Biological Process | GO:0051177 | meiotic sister chromatid cohesion |
| Biological Process | GO:0007130 | synaptonemal complex assembly |
Reference
PMID: N/A