Search Results
Overview
| Uniprot ID | Q8N7J2 |
|---|---|
| Protein Name | APC membrane recruitment protein 2 |
| Gene Name | AMER2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 503 | IPIEPHPKEEPKHPE |
Function
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex
Protein Sequence
10
METSRSRGGG
20
GAVSERGGAG
30
ASVGVCRRKA
40
EAGAGTGTLA
50
ADMDLHCDCA
60
AETPAAEPPS
70
GKINKAAFKL
80
FKKRKSGGTM
90
PSIFGVKNKG
100
DGKSSGPTGL
110
VRSRTHDGLA
120
EVLVLESGRK
130
EEPRGGGDSG
140
GGGGGRPNPG
150
PPRAAGPGGG
160
SLASSSVAKS
170
HSFFSLLKKN
180
GRSENGKGEP
190
VDASKAGGKQ
200
KRGLRGLFSG
210
MRWHRKDKRA
220
KAEAAEGRAP
230
GGGLILPGSL
240
TASLECVKEE
250
TPRAAREPEE
260
PSQDAPRDPA
270
GEPAGGEEVP
280
APADRAPARS
290
CREAEGLAHP
300
GDTGARGEDA
310
AGHRRAEPGP
320
GEVRTAEDAS
330
RTGAVPVKTV
340
PLVDSEGGSG
350
RAPAAPDPAS
360
VDPPSDPSAD
370
RICLMFSDVT
380
SLKSFDSLTG
390
CGDIIADQEE
400
EAGPSCDKHV
410
PGPGKPALSK
420
KNPGVVAYQG
430
GGEEMASPDE
440
VDDTYLQEFW
450
DMLSQTEEQG
460
PEPQEGAAKV
470
AAALETKVVP
480
ETPKDTRCVE
490
AAKDASSVKR
500
RRLNRIPIEP
510
HPKEEPKHPE
520
KEQQEGVPNS
530
DEGYWDSTTP
540
GPEEDSSSSG
550
KKAGIPRDSY
560
SGDALYDLYA
570
DPDGSPATLP
580
GGKDNEETSS
590
LSRLKPVSPG
600
TITCPLRTPG
610
SLLKDSKIPI
620
SIKHLTNLPS
630
SHPVVHQQPS
640
RSEMPRTKIP
650
VSKVLVRRVS
660
NRGLAGTTIR
670
ATACHDSAKK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process | GO:0007398 | ectoderm development |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0060828 | regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.