Search Results
Overview
| Uniprot ID | Q8N7U6 |
|---|---|
| Protein Name | EF-hand domain-containing family member B |
| Gene Name | EFHB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 181 | ESTCVLMKPNTEIKL |
Function
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (PubMed:30481768)
Protein Sequence
10
MNMEIGHPHE
20
GKDDLGDKRV
30
IMGTKFPMEL
40
GIRVGLGKED
50
SRCGESPVVS
60
NKCEGRMAPP
70
ETKFPLSKGL
80
EMGLERQNIS
90
RTVMQRGSLG
100
VDSVSASQGT
110
KPSLLPGRMG
120
LENESLLAGY
130
THERIIQPPL
140
GRVCGSSQAA
150
GSRRAPLASG
160
PEGVEELVGK
170
PAFVMEPRQE
180
MEKESTCVLM
190
KPNTEIKLPV
200
EVDIGLTQAE
210
GPDETKNTEP
220
QMGLVIEPPQ
230
CQFAQQHEQR
240
KEAGNIESGV
250
EPPDRIRPIY
260
SGKFFDRTPC
270
WPSAGKVIPV
280
GYRVATCLTE
290
KLPRLITPPE
300
AKKYFNFRYP
310
PAGVERVFYG
320
RANDPQIAPY
330
LTHGIRSKIS
340
VLANTLINPQ
350
PITTFQQKIK
360
DKKESIYLSN
370
RRAPLGKSHD
380
QAPGLPKGMD
390
TTNTTFGTAV
400
IKEYSAKDVV
410
NPPKSYEEVF
420
KEGNEGHDLY
430
VVSHNDYYAG
440
EAKNRKYNPS
450
SFHRCSVYGV
460
PTPHFNDGRA
470
MAKSLYWLHE
480
LQMKRGAKFV
490
SKRADDFKEK
500
FQHKLGRVLD
510
PIAETMNVPP
520
DCTFGACLRP
530
EEYGVGDLIH
540
NRLPDEYLRG
550
KDRQRALIAA
560
VRHHLKKVNY
570
QKFDTLLAAF
580
RHYDKKGDGM
590
IDKDELQEAC
600
DQANLSLDDK
610
LLDQLFDYCD
620
VDNDGFINYL
630
EFANFLNWKD
640
KMLLKEYEER
650
VIIKGRKPDC
660
VNPTEANVEE
670
PEQTLLIKPE
680
DIVLKEAGST
690
EKTLRTLLRP
700
SDKVSNYYKT
710
TSSEINAIVG
720
AIPSTCYPIC
730
GVPTIRSDIP
740
APRIRRISDR
750
TNYGEEGSAY
760
SLLYPTIFAR
770
KGVFERDFFK
780
TRSKEEIAEI
790
LCNIGVKLSD
800
EEFENVWNLA
810
SKKHHRGEVC
820
VENIRNVLDE
830
LRHADRIKCK
TLM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0160111 | axonemal A tubule inner sheath |
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061891 | calcium ion sensor activity |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0032091 | negative regulation of protein binding |
| Biological Process | GO:0070884 | regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:2001256 | regulation of store-operated calcium entry |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.