Search Results

Overview

Uniprot IDQ8N7Z5
Protein NameAnkyrin repeat domain-containing protein 31
Gene NameANKRD31
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1379 DNVLAKQKAERDDLA
1387 AERDDLAKKYRVSIE
454 NMHSARFKNGKQIRK

Function

Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes

Protein Sequence

10 MEEGVQAPDW 20 DSDETVIEGS 30 VTESDLEEKE 40 LPWRRLLFDQ 50 DASLKSEFSL 60 HPDTRGMCKG 70 MPSPEIQLGF 80 KLREDLQEQM 90 NKNKMMPVLS 100 EDTILQSQDE 110 TERNQALLQT 120 RKNCSMFIGS 130 FRQSGLSLNH 140 QNIEGPEAES 150 PEVLPHIEKE 160 LSEGRDSPEV 170 SLLSGTAITV 180 SDTVAVKETS 190 LVEPEKILAA 200 PNTFFEPRKE 210 VTMTMTSEET 220 KDEESSLETF 230 VSALESLLTS 240 PESTQEERLF 250 ELVSDFDRKE 260 LMNPLSDSLS 270 SISIPLNSWS 280 ACHRDLLEDA 290 KDDALPAELL 300 EALNTLSEAK 310 VETICHRKEG 320 GSSLIARNEC 330 LEVEFNTSQT 340 NEDCTQIAET 350 LQDPNPSGLQ 360 TLAHQNITSC 370 EPLSNKRNSN 380 SVTNSSDQET 390 ACVLRRSSRL 400 EKLKVSRDAK 410 YSDHMYKMPE 420 KILPKILGCE 430 DLTNNNSSAQ 440 NFRMQDPALM 450 IDGKEKNMHS 460 ARFKNGKQIR 470 KNEQFSGKKE 480 KMKVNKISLH 490 SINRRNIFGE 500 NLVYKAALHD 510 DADLVHHCIK 520 KGGNVNQPSY 530 AGWTALHEAS 540 VGGFYRTASE 550 LLKGGADVNI 560 KGLYQITPLH 570 DAVMNGHYKV 580 AELLLLNGAD 590 PLFRNDDGKC 600 ALDEAKDLCM 610 KRLLERYIPK 620 HQKCLTSAQR 630 SSIDPLDIED 640 VYQHKKPKFS 650 SKSHIWHVYN 660 ENSNRQKLEH 670 VKVNKGSKAS 680 LFINKEDVYE 690 YYQKDPKNTK 700 FGKSKHKQST 710 LDQIYSTGLR 720 KGNLHNVKDP 730 NTNVPKGIGR 740 RKTQHKRTQV 750 DDVDCNPRKI 760 LAVSPSRRIN 770 RLVTYQQHIP 780 ETHNDLPEEL 790 CEPSSLTLSS 800 LRNGLDSSTE 810 ACSVSKEKHI 820 QNLDLSDSQE 830 VQCLELESVD 840 QTEAVSFPGL 850 LLHKEIKLPV 860 VTTDKQPHTL 870 QEQHHVLYKS 880 HENSNLVPKD 890 ERFNKWENSF 900 LSFVKENSDN 910 DDDDDCSTSE 920 KAITSKKVLC 930 STGGKKHYNF 940 KENLTNKKEM 950 GFQQFLLSED 960 HLSQENELKA 970 VSLTTLPEQE 980 AVNFSYSDNA 990 VISEHVANYE 1000 QCIFGPSFDH 1010 SNGNPEQNSL 1020 ACMRTLLTHE 1030 ASKLTNHVEL 1040 FKKPQDYIPR 1050 APTFLMNQTD 1060 THIVEKMAKN 1070 CDTERNYIDR 1080 DQKIIYSNEP 1090 LSIVAHSQVI 1100 ETTKVEKRRQ 1110 NHLESETIHN 1120 IDSHSTDNMS 1130 KELANISKLS 1140 QREKKEISHK 1150 PGMKAGRINK 1160 RNARGESQLH 1170 LAVRRGNLPL 1180 VKALIESGAD 1190 VNLNDNAGWT 1200 PLHEASNEGS 1210 IDIIVELLKA 1220 GAKVNCENID 1230 GILPLHDAVA 1240 NNHLKAAEIL 1250 LQNGANPNQK 1260 DQKQKSALDE 1270 ADDEKMKELL 1280 RSYGAIETVN 1290 RDESDAIVNE 1300 KIPAVRSKRH 1310 KQCFCDDGKT 1320 IDSSSLSHQE 1330 RSRESLSVHQ 1340 TLSAILQDIE 1350 EKQEYLLEFE 1360 IRNPEDAEQY 1370 IEKMLKIKKI 1380 MDNVLAKQKA 1390 ERDDLAKKYR 1400 VSIESFKHGA 1410 LREQLANLAA 1420 RQKSLLVVAK 1430 KQKKISLKIQ 1440 NCRNVTSLPC 1450 LSLRKLPPRS 1460 EISSEKDSQE 1470 LTSLENLEHP 1480 QSGSLSPVSG 1490 SMQETQLSLE 1500 TWNYSQNTNI 1510 CLNSEAVRRG 1520 EFSGNDMNSK 1530 QNGSDCTLDG 1540 FPKSRHSDGT 1550 EKNKLPSQPV 1560 AFIGQTEYSQ 1570 KENDLTEATD 1580 KDHEFYVSSP 1590 VIGKLNISET 1600 ASVLAENAAH 1610 PSNIICDQDL 1620 SNYDPKRGNR 1630 KTSSQQSPTG 1640 ASESLAHQGI 1650 AVLGSDTVHQ 1660 MKPYLKKSVS 1670 VVPCADDSQI 1680 SSSSGSGQQD 1690 TIKKALNYST 1700 APKKKCIQIK 1710 DLILLGRINP 1720 GNNILEFKTQ 1730 ETTHKASILL 1740 NGKLKVESGQ 1750 IYKNPVTWLK 1760 DLLGGNSYVT 1770 WNYAWSKVTY 1780 LGKELLRYVS 1790 EDAPILPEPN 1800 SVPQQYQPCL 1810 PEVACLDDPV 1820 QEPNKSMFEK 1830 TKFGQGTSRE 1840 SMQSSPRYLQ 1850 INEILLISDQ 1860 EFLPCHIMDQ 1870 HWKFCVECEE LTP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Biological Process GO:0007129 homologous chromosome pairing at meiosis
Biological Process GO:0010780 meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
Biological Process GO:1903343 positive regulation of meiotic DNA double-strand break formation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.