Search Results

Overview

Uniprot ID	Q8N8E3
Protein Name	Centrosomal protein of 112 kDa
Gene Name	CEP112
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
357	SLNNDWEKKLHNAVA

Function

Recruits mRNAs essential for sperm development, such as CFAP61 and FSIP2 mRNAs, into phase-separated condensates, thereby regulating their translation through a mechanism of liquid-liquid phase separation

Protein Sequence

10 MEVGSEEEKW 20 EKLDAEFDHF 30 VVDMKPFVLK 40 LPHRTERQRC 50 ALWIRKLCEP 60 SGTGAGIMGR 70 KNRNLYAKLL 80 LHMLKRGALE 90 GPFTHRPEPG 100 TLKILPSYMS 110 IYFDEPNPAR 120 AKGSSPEGLP 130 AWVLGELETS 140 EHKLNESWKL 150 SSGEDNTLVQ 160 SPTDVYSREQ 170 YTGKLRVRSH 180 SLSPTHREDG 190 QNITPKICEV 200 YSKKSPVSLD 210 DSDIEARLNS 220 WNLGIENPRY 230 LRQKPIPVSL 240 MTPKFSLRKS 250 SSFHDDHFLS 260 RIREKELDMK 270 TKMMEAKFHE 280 EKLKLQQKHD 290 ADVQKILERK 300 NNEIEELKTL 310 YRSKQHETEE 320 TIRKLEKKVQ 330 TLIRDCQVIR 340 ETKEDQIAEL 350 KKICEQSTES 360 LNNDWEKKLH 370 NAVAEMEQEK 380 FDLQKQHTEN 390 IQELLEDTNV 400 RLNKMESEYM 410 AQTQSTNHMI 420 KELEARVQQL 430 TGEAENSNLQ 440 RQKLIQEKAE 450 LERCYQITCS 460 ELQEVKARRN 470 TLHKEKDHLV 480 NDYEQNMKLL 490 QTKYDADINL 500 LKQEHALSAS 510 KASSMIEELE 520 QNVCQLKQQL 530 QESELQRKQQ 540 LRDQENKFQM 550 EKSHLKHIYE 560 KKAHDLQSEL 570 DKGKEDTQKK 580 IHKFEEALKE 590 KEEQLTRVTE 600 VQRLQAQQAD 610 AALEEFKRQV 620 ELNSEKVYAE 630 MKEQMEKVEA 640 DLTRSKSLRE 650 KQSKEFLWQL 660 EDIRQRYEQQ 670 IVELKLEHEQ 680 EKTHLLQQHN 690 AEKDSLVRDH 700 EREIENLEKQ 710 LRAANMEHEN 720 QIQEFKKRDA 730 QVIADMEAQV 740 HKLREELINV 750 NSQRKQQLVE 760 LGLLREEEKQ 770 RATREHEIVV 780 NKLKAESEKM 790 KIELKKTHAA 800 ETEMTLEKAN 810 SKLKQIEKEY 820 TQKLAKSSQI 830 IAELQTTISS 840 LKEENSQQQL 850 AAERRLQDVR 860 QKFEDEKKQL 870 IRDNDQAIKV 880 LQDELENRSN 890 QVRCAEKKLQ 900 HKELESQEQI 910 TYIRQEYETK 920 LKGLMPASLR 930 QELEDTISSL 940 KSQVNFLQKR 950 ASILQEELTT YQGRR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005814	centriole
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule
Cellular Component	GO:0060077	inhibitory synapse
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0140693	molecular condensate scaffold activity

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.