Search Results
Overview
| Uniprot ID | Q8N8N7 |
|---|---|
| Protein Name | Prostaglandin reductase 2 |
| Gene Name | PTGR2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 210 | DAAINYKKDNVAEQL |
Function
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)
Protein Sequence
10
MIVQRVVLNS
20
RPGKNGNPVA
30
ENFRMEEVYL
40
PDNINEGQVQ
50
VRTLYLSVDP
60
YMRCRMNEDT
70
GTDYITPWQL
80
SQVVDGGGIG
90
IIEESKHTNL
100
TKGDFVTSFY
110
WPWQTKVILD
120
GNSLEKVDPQ
130
LVDGHLSYFL
140
GAIGMPGLTS
150
LIGIQEKGHI
160
TAGSNKTMVV
170
SGAAGACGSV
180
AGQIGHFLGC
190
SRVVGICGTH
200
EKCILLTSEL
210
GFDAAINYKK
220
DNVAEQLRES
230
CPAGVDVYFD
240
NVGGNISDTV
250
ISQMNENSHI
260
ILCGQISQYN
270
KDVPYPPPLS
280
PAIEAIQKER
290
NITRERFLVL
300
NYKDKFEPGI
310
LQLSQWFKEG
320
KLKIKETVIN
330
GLENMGAAFQ
340
SMMTGGNIGK
350
QIVCISEEIS
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0047522 | 15-oxoprostaglandin 13-reductase [NAD(P)+] activity |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.