Search Results

Overview

Uniprot IDQ8N8S7
Protein NameProtein enabled homolog
Gene NameENAH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
461 RRRRIAEKGSTIETE
519 SRRDSPRKNQIVFDN
536 YDSLHRPKSTPLSQP

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity)

Protein Sequence

10 MSEQSICQAR 20 AAVMVYDDAN 30 KKWVPAGGST 40 GFSRVHIYHH 50 TGNNTFRVVG 60 RKIQDHQVVI 70 NCAIPKGLKY 80 NQATQTFHQW 90 RDARQVYGLN 100 FGSKEDANVF 110 ASAMMHALEV 120 LNSQETGPTL 130 PRQNSQLPAQ 140 VQNGPSQEEL 150 EIQRRQLQEQ 160 QRQKELERER 170 LERERMERER 180 LERERLERER 190 LERERLEQEQ 200 LERERQERER 210 QERLERQERL 220 ERQERLERQE 230 RLDRERQERQ 240 ERERLERLER 250 ERQERERQEQ 260 LEREQLEWER 270 ERRISSAAAP 280 ASVETPLNSV 290 LGDSSASEPG 300 LQAASQPAET 310 PSQQGIVLGP 320 LAPPPPPPLP 330 PGPAQASVAL 340 PPPPGPPPPP 350 PLPSTGPPPP 360 PPPPPLPNQV 370 PPPPPPPPAP 380 PLPASGFFLA 390 SMSEDNRPLT 400 GLAAAIAGAK 410 LRKVSRMEDT 420 SFPSGGNAIG 430 VNSASSKTDT 440 GRGNGPLPLG 450 GSGLMEEMSA 460 LLARRRRIAE 470 KGSTIETEQK 480 EDKGEDSEPV 490 TSKASSTSTP 500 EPTRKPWERT 510 NTMNGSKSPV 520 ISRRDSPRKN 530 QIVFDNRSYD 540 SLHRPKSTPL 550 SQPSANGVQT 560 EGLDYDRLKQ 570 DILDEMRKEL 580 TKLKEELIDA 590 IRQELSKSNT A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005522 profilin binding
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0050699 WW domain binding
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0070358 actin polymerization-dependent cell motility
Biological Process GO:0007411 axon guidance
Biological Process GO:0099188 postsynaptic cytoskeleton organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.