Search Results
Overview
| Uniprot ID | Q8N9L9 |
|---|---|
| Protein Name | Peroxisomal succinyl-coenzyme A thioesterase |
| Gene Name | ACOT4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 415 | KHLGGTQKTAVPKL* |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157). Functions as a peroxisomal succinyl-coenzyme A thioesterase that can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157)
Protein Sequence
10
MSATLILEPP
20
GRCCWNEPVR
30
IAVRGLAPEQ
40
RVTLRASLRD
50
EKGALFRAHA
60
RYCADARGEL
70
DLERAPALGG
80
SFAGLEPMGL
90
LWALEPEKPF
100
WRFLKRDVQI
110
PFVVELEVLD
120
GHDPEPGRLL
130
CQAQHERHFL
140
PPGVRRQSVR
150
AGRVRATLFL
160
PPGPGPFPGI
170
IDIFGIGGGL
180
LEYRASLLAG
190
HGFATLALAY
200
YNFEDLPNNM
210
DNISLEYFEE
220
AVCYMLQHPQ
230
VKGPGIGLLG
240
ISLGADICLS
250
MASFLKNVSA
260
TVSINGSGIS
270
GNTAINYKHS
280
SIPPLGYDLR
290
RIKVAFSGLV
300
DIVDIRNALV
310
GGYKNPSMIP
320
IEKAQGPILL
330
IVGQDDHNWR
340
SELYAQTVSE
350
RLQAHGKEKP
360
QIICYPGTGH
370
YIEPPYFPLC
380
PASLHRLLNK
390
HVIWGGEPRA
400
HSKAQEDAWK
410
QILAFFCKHL
420
GGTQKTAVPK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047617 | fatty acyl-CoA hydrolase activity |
| Molecular Function | GO:0004778 | succinyl-CoA hydrolase activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0043649 | dicarboxylic acid catabolic process |
| Biological Process | GO:0043648 | dicarboxylic acid metabolic process |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0032788 | saturated monocarboxylic acid metabolic process |
| Biological Process | GO:0046459 | short-chain fatty acid metabolic process |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0032789 | unsaturated monocarboxylic acid metabolic process |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.