Search Results

Overview

Uniprot ID	Q8N9N2
Protein Name	Activating signal cointegrator 1 complex subunit 1
Gene Name	ASCC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
331	NLYTAEGKYIFKERE

Function

Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction

Protein Sequence

10 MEVLRPQLIR 20 IDGRNYRKNP 30 VQEQTYQHEE 40 DEEDFYQGSM 50 ECADEPCDAY 60 EVEQTPQGFR 70 STLRAPSLLY 80 NLIHLNTSND 90 CGFQKITLDC 100 QNIYTWKSRH 110 IVGKRGDTRK 120 KIEMETKTSI 130 SIPKPGQDGE 140 IVITGQHRNG 150 VISARTRIDV 160 LLDTFRRKQP 170 FTHFLAFFLN 180 EVEVQEGFLR 190 FQEEVLAKCS 200 MDHGVDSSIF 210 QNPKKLHLTI 220 GMLVLLSEEE 230 IQQTCEMLQQ 240 CKEEFINDIS 250 GGKPLEVEMA 260 GIEYMNDDPG 270 MVDVLYAKVH 280 MKDGSNRLQE 290 LVDRVLERFQ 300 ASGLIVKEWN 310 SVKLHATVMN 320 TLFRKDPNAE 330 GRYNLYTAEG 340 KYIFKERESF 350 DGRNILKSFA 360 LLPRLEYNDA 370 ISAHCNLCLP 380 GSSDSPASAS 390 QVAGITGVSD 400 AYSQSLPGKS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005667	transcription regulator complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006307	DNA alkylation repair
Biological Process	GO:0006260	DNA replication
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006355	regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.