Overview
| Uniprot ID | Q8N9N5 |
|---|
| Protein Name | Protein BANP |
|---|
| Gene Name | BANP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 275 |
SNLSGQGKHGKKQLD |
Function
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing (PubMed:26080397). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (PubMed:26080397)
Protein Sequence
10
MMSEHDLADV
20
VQIAVEDLSP
30
DHPVVLENHV
40
VTDEDEPALK
50
RQRLEINCQD
60
PSIKTICLRL
70
DSIEAKLQAL
80
EATCKSLEEK
90
LDLVTNKQHS
100
PIQVPMVAGS
110
PLGATQTCNK
120
VRCVVPQTTV
130
ILNNDRQNAI
140
VAKMEDPLSN
150
RAPDSLENVI
160
SNAVPGRRQN
170
TIVVKVPGQE
180
DSHHEDGESG
190
SEASDSVSSC
200
GQAGSQSIGS
210
NVTLITLNSE
220
EDYPNGTWLG
230
DENNPEMRVR
240
CAIIPSDMLH
250
ISTNCRTAEK
260
MALTLLDYLF
270
HREVQAVSNL
280
SGQGKHGKKQ
290
LDPLTIYGIR
300
CHLFYKFGIT
310
ESDWYRIKQS
320
IDSKCRTAWR
330
RKQRGQSLAV
340
KSFSRRTPNS
350
SSYCPSEPMM
360
STPPPASELP
370
QPQPQPQALH
380
YALANAQQVQ
390
IHQIGEDGQV
400
QVGHLHIAQV
410
PQGEQVQITQ
420
DSEGNLQIHH
430
VGQDGQLLEA
440
TRIPCLLAPS
450
VFKASSGQVL
460
QGAQLIAVAS
470
SDPAAAGVDG
480
SPLQGSDIQV
490
QYVQLAPVSD
500
HTAGAQTAEA
510
LQPTLQPEMQ
LEHGAIQIQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.