Overview
| Uniprot ID | Q8NA31 |
|---|
| Protein Name | Telomere repeats-binding bouquet formation protein 1 |
|---|
| Gene Name | TERB1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 533 |
HEETTFEKNFVSQSS |
Function
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity
Protein Sequence
10
MESEDTKKTQ
20
EMKTDLNLLL
30
ECLKYQMDNA
40
FSQKEALVTI
50
HSICQQNSNA
60
SVYFREIGGL
70
MFVKNLAKSS
80
EHSMVKEAAL
90
YTLGAIAEKN
100
VYCQQTLCTS
110
ELFEDLTWFL
120
SNDSNINLKR
130
MSVYVILVLV
140
SNNRTGQTLV
150
RETGCITVLS
160
RLFRTVISKH
170
ELDLSDKNVF
180
QSYQLWSSVC
190
STLCVCVNNP
200
QNDENQMFCC
210
SLFPHANEWL
220
KNCTTPEIIR
230
PICSFIGLTL
240
ANNTYVQKYF
250
VSVGGLDVLS
260
QVLMQLESDS
270
HETLSSAKLA
280
VVVTKTVDAC
290
IADNPTFGIV
300
LSKYHIVSKL
310
LALLLHESLD
320
SGEKFSIMLT
330
LGHCTEDCEE
340
NQYDLFKNNG
350
LPLMIQALTE
360
SQNEELNKAA
370
TFVLHNCKKI
380
TEKLSLSLGE
390
YPFDENETQQ
400
LKDISVKENN
410
LEEHWRKAKE
420
ILHRIEQLER
430
EGNEEEIQRE
440
NYQDNISSMN
450
ISIQNTWKHL
460
HADRIGRGSK
470
AEDEDKSHSR
480
QLQSYKSHGV
490
MSKACTNDDQ
500
MKTPLKSANP
510
VHACYRESEQ
520
NKTLYKAKSS
530
CNQNLHEETT
540
FEKNFVSQSS
550
DHVFKHPVHI
560
AKNIKQQLPV
570
TDPFTLCSDI
580
INKEVVSFLA
590
TPSCSEMLTY
600
RCSGCIAVEK
610
SLNSRNFSKL
620
LHSCPYQCDR
630
HKVIVEAEDR
640
YKSELRKSLI
650
CNKKILLTPR
660
RRQRLSNEST
670
TPGGIKKRRI
680
RKNFTEEEVN
690
YLFNGVKKMG
700
NHWNSILWSF
710
PFQQGRKAVD
720
LAHKYHKLTK
HPTCAAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005637 |
nuclear inner membrane |
| Cellular Component |
GO:0070187 |
shelterin complex |
| Biological Process |
GO:0007129 |
homologous chromosome pairing at meiosis |
| Biological Process |
GO:0070197 |
meiotic attachment of telomere to nuclear envelope |
| Biological Process |
GO:0045141 |
meiotic telomere clustering |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.