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Overview

Uniprot IDQ8NAP3
Protein NameZinc finger and BTB domain-containing protein 38
Gene NameZBTB38
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
857 KRHILGSKLFYKRGR

Function

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity)

Protein Sequence

10 MTVMSLSRDL 20 KDDFHSDTVL 30 SILNEQRIRG 40 ILCDVTIIVE 50 DTKFKAHSNV 60 LAASSLYFKN 70 IFWSHTICIS 80 SHVLELDDLK 90 AEVFTEILNY 100 IYSSTVVVKR 110 QETVTDLAAA 120 GKKLGISFLE 130 DLTDRNFSNS 140 PGPYVFCITE 150 KGVVKEEKNE 160 KRHEEPAITN 170 GPRITNAFSI 180 IETENSNNMF 190 SPLDLRASFK 200 KVSDSMRTAS 210 LCLERTDVCH 220 EAEPVRTLAE 230 HSYAVSSVAE 240 AYRSQPVREH 250 DGSSPGNTGK 260 ENCEALAAKP 270 KTCRKPKTFS 280 IPQDSDSATE 290 NIPPPPVSNL 300 EVNQERSPQP 310 AAVLTRSKSP 320 NNEGDVHFSR 330 EDENQSSDVP 340 GPPAAEVPPL 350 VYNCSCCSKA 360 FDSSTLLSAH 370 MQLHKPTQEP 380 LVCKYCNKQF 390 TTLNRLDRHE 400 QICMRSSHMP 410 IPGGNQRFLE 420 NYPTIGQNGG 430 SFTGPEPLLS 440 ENRIGEFSST 450 GSTLPDTDHM 460 VKFVNGQMLY 470 SCVVCKRSYV 480 TLSSLRRHAN 490 VHSWRRTYPC 500 HYCNKVFALA 510 EYRTRHEIWH 520 TGERRYQCIF 530 CLETFMTYYI 540 LKNHQKSFHA 550 IDHRLSISKK 560 TANGGLKPSV 570 YPYKLYRLLP 580 MKCKRAPYKS 590 YRNSSYENAR 600 ENSQMNESAP 610 GTYVVQNPHS 620 SELPTLNFQD 630 TVNTLTNSPA 640 IPLETSACQD 650 IPTSANVQNA 660 EGTKWGEEAL 670 KMDLDNNFYS 680 TEVSVSSTEN 690 AVSSDLRAGD 700 VPVLSLSNSS 710 ENAASVISYS 720 GSAPSVIVHS 730 SQFSSVIMHS 740 NAIAAMTSSN 750 HRAFSDPAVS 760 QSLKDDSKPE 770 PDKVGRFASR 780 PKSIKEKKKT 790 TSHTRGEIPE 800 ESNYVADPGG 810 SLSKTTNIAE 820 ETSKIETYIA 830 KPALPGTSTN 840 SNVAPLCQIT 850 VKIGNEAIVK 860 RHILGSKLFY 870 KRGRRPKYQM 880 QEEPLPQGND 890 PEPSGDSPLG 900 LCQSECMEMS 910 EVFDDASDQD 920 STDKPWRPYY 930 NYKPKKKSRQ 940 LKKMRKVNWR 950 KEHGNRSPSH 960 KCKYPAELDC 970 AVGKAPQDKP 980 FEEEETKEMP 990 KLQCELCDGD 1000 KAVGAGNQGR 1010 PHRHLTSRPY 1020 ACELCAKQFQ 1030 SPSTLKMHMR 1040 CHTGEKPYQC 1050 KTCGRCFSVQ 1060 GNLQKHERIH 1070 LGLKEFVCQY 1080 CNKAFTLNET 1090 LKIHERIHTG 1100 EKRYHCQFCF 1110 QRFLYLSTKR 1120 NHEQRHIREH 1130 NGKGYACFQC 1140 PKICKTAAAL 1150 GMHQKKHLFK 1160 SPSQQEKIGD 1170 VCHENSNPLE 1180 NQHFIGSEDN 1190 DQKDNIQTGV ENVVL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0008327 methyl-CpG binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

PMID: N/A