Search Results

Overview

Uniprot ID	Q8NAV1
Protein Name	Pre-mRNA-splicing factor 38A
Gene Name	PRPF38A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
7	*MANRTVKDAHSIHG

Function

Involved in pre-mRNA splicing as a component of the spliceosome

Protein Sequence

10 MANRTVKDAH 20 SIHGTNPQYL 30 VEKIIRTRIY 40 ESKYWKEECF 50 GLTAELVVDK 60 AMELRFVGGV 70 YGGNIKPTPF 80 LCLTLKMLQI 90 QPEKDIIVEF 100 IKNEDFKYVR 110 MLGALYMRLT 120 GTAIDCYKYL 130 EPLYNDYRKI 140 KSQNRNGEFE 150 LMHVDEFIDE 160 LLHSERVCDI 170 ILPRLQKRYV 180 LEEAEQLEPR 190 VSALEEDMDD 200 VESSEEEEEE 210 DEKLERVPSP 220 DHRRRSYRDL 230 DKPRRSPTLR 240 YRRSRSRSPR 250 RRSRSPKRRS 260 PSPRRERHRS 270 KSPRRHRSRS 280 RDRRHRSRSK 290 SPGHHRSHRH 300 RSHSKSPERS 310 KKSHKKSRRG NE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0071011	precatalytic spliceosome
Cellular Component	GO:0071005	U2-type precatalytic spliceosome
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.