Search Results

Overview

Uniprot IDQ8NBF2
Protein NameNHL repeat-containing protein 2
Gene NameNHLRC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
596 KTLPKLPKSAPSIRL

Function

Required for normal embryonic development

Protein Sequence

10 MAAPGGRGRS 20 LSGLLPAQTS 30 LEYALLDAVT 40 QQEKDSLVYQ 50 YLQKVDGWEQ 60 DLSVPEFPEG 70 LEWLNTEEPI 80 SVYKDLCGKI 90 VVLDFFTYCC 100 INCIHLLPDL 110 HALEHTYSDK 120 DGLLIIGVHS 130 AKFPNEKVLD 140 NIKSAVLRYN 150 ITHPMVNDAD 160 ASLWQELEVS 170 CWPTLVILGP 180 RGNMLFSLIG 190 EGHKDKLFLY 200 TSIALKYYKD 210 RGQIRDNKIG 220 IKLYKDSLPP 230 SPLLFPGKVT 240 VDQVTDRLVI 250 ADTGHHRILV 260 VWKNGQIQYS 270 IGGPNPGRKD 280 GIFSESTFNS 290 PQGVAIMNNI 300 IYVADTENHL 310 IRKIDLEAEK 320 VSTVAGIGIQ 330 GTDKEGGAKG 340 EQQPISSPWD 350 VVFGTSGSEV 360 QRGDILWIAM 370 AGTHQIWALL 380 LDSGKLPKKN 390 ELTKGTCLRF 400 AGSGNEENRN 410 NAYPHKAGFA 420 QPSGLSLASE 430 DPWSCLFVAD 440 SESSTVRTVS 450 LKDGAVKHLV 460 GGERDPMNLF 470 AFGDVDGVGI 480 NAKLQHPLGV 490 TWDKKRNLLY 500 VADSYNHKIK 510 VVDPKTKNCT 520 TLAGTGDTNN 530 VTSSSFTEST 540 FNEPGGLCIG 550 ENGELLYVAD 560 TNNHQIKVMD 570 LETKMVSVLP 580 IFRSENAVVD 590 GPFLVEKQKT 600 LPKLPKSAPS 610 IRLSPVTACA 620 GQTLQFKLRL 630 DLPSGSKLTE 640 GVSSCWFLTA 650 EGNEWLLQGQ 660 IAAGDIENIS 670 SQPTISLQIP 680 DDCLSLEAIV 690 SVSVFLYYCS 700 ADSSACMMKA 710 ILFSQPLQIT 720 DTQQGCIAPV ELRYVF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0031093 platelet alpha granule lumen

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.