Search Results

Overview

Uniprot IDQ8NBJ5
Protein NameProcollagen galactosyltransferase 1
Gene NameCOLGALT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
470 DLIYVGRKRMQVEHP
508 ISLQGARKLLAAEPL
593 WDRAKSQKMREQQAL

Function

Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317)

Protein Sequence

10 MAAAPRAGRR 20 RGQPLLALLL 30 LLLAPLPPGA 40 PPGADAYFPE 50 ERWSPESPLQ 60 APRVLIALLA 70 RNAAHALPTT 80 LGALERLRHP 90 RERTALWVAT 100 DHNMDNTSTV 110 LREWLVAVKS 120 LYHSVEWRPA 130 EEPRSYPDEE 140 GPKHWSDSRY 150 EHVMKLRQAA 160 LKSARDMWAD 170 YILFVDADNL 180 ILNPDTLSLL 190 IAENKTVVAP 200 MLDSRAAYSN 210 FWCGMTSQGY 220 YKRTPAYIPI 230 RKRDRRGCFA 240 VPMVHSTFLI 250 DLRKAASRNL 260 AFYPPHPDYT 270 WSFDDIIVFA 280 FSCKQAEVQM 290 YVCNKEEYGF 300 LPVPLRAHST 310 LQDEAESFMH 320 VQLEVMVKHP 330 PAEPSRFISA 340 PTKTPDKMGF 350 DEVFMINLRR 360 RQDRRERMLR 370 ALQAQEIECR 380 LVEAVDGKAM 390 NTSQVEALGI 400 QMLPGYRDPY 410 HGRPLTKGEL 420 GCFLSHYNIW 430 KEVVDRGLQK 440 SLVFEDDLRF 450 EIFFKRRLMN 460 LMRDVEREGL 470 DWDLIYVGRK 480 RMQVEHPEKA 490 VPRVRNLVEA 500 DYSYWTLAYV 510 ISLQGARKLL 520 AAEPLSKMLP 530 VDEFLPVMFD 540 KHPVSEYKAH 550 FSLRNLHAFS 560 VEPLLIYPTH 570 YTGDDGYVSD 580 TETSVVWNNE 590 HVKTDWDRAK 600 SQKMREQQAL 610 SREAKNSDVL 620 QSPLDSAARD EL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0016020 membrane
Molecular Function GO:0050211 procollagen galactosyltransferase activity
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:1904028 positive regulation of collagen fibril organization
Biological Process GO:0180062 protein O-linked glycosylation via galactose

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.