Search Results
Overview
| Uniprot ID | Q8NBQ5 |
|---|---|
| Protein Name | Estradiol 17-beta-dehydrogenase 11 |
| Gene Name | HSD17B11 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | EDIYSSAKKVKAEIG |
| 62 | EFAKLKSKLVLWDIN |
| 86 | KCKGLGAKVHTFVVD |
Function
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma
Protein Sequence
10
MKFLLDILLL
20
LPLLIVCSLE
30
SFVKLFIPKR
40
RKSVTGEIVL
50
ITGAGHGIGR
60
LTAYEFAKLK
70
SKLVLWDINK
80
HGLEETAAKC
90
KGLGAKVHTF
100
VVDCSNREDI
110
YSSAKKVKAE
120
IGDVSILVNN
130
AGVVYTSDLF
140
ATQDPQIEKT
150
FEVNVLAHFW
160
TTKAFLPAMT
170
KNNHGHIVTV
180
ASAAGHVSVP
190
FLLAYCSSKF
200
AAVGFHKTLT
210
DELAALQITG
220
VKTTCLCPNF
230
VNTGFIKNPS
240
TSLGPTLEPE
250
EVVNRLMHGI
260
LTEQKMIFIP
270
SSIAFLTTLE
280
RILPERFLAV
290
LKRKISVKFD
300
AVIGYKMKAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005811 | lipid droplet |
| Molecular Function | GO:0004303 | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0016229 | steroid dehydrogenase activity |
| Biological Process | GO:0006710 | androgen catabolic process |
| Biological Process | GO:0006703 | estrogen biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.