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Overview

Uniprot IDQ8NBS9
Protein NameThioredoxin domain-containing protein 5
Gene NameTXNDC5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
150 KPGQEAVKYQGPRDF
244 SETVKIGKVDCTQHY
366 TWEELSKKEFPGLAG
390 AERNICSKYSVRGYP

Function

Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds

Protein Sequence

10 MPARPGRLLP 20 LLARPAALTA 30 LLLLLLGHGG 40 GGRWGARAQE 50 AAAAAADGPP 60 AADGEDGQDP 70 HSKHLYTADM 80 FTHGIQSAAH 90 FVMFFAPWCG 100 HCQRLQPTWN 110 DLGDKYNSME 120 DAKVYVAKVD 130 CTAHSDVCSA 140 QGVRGYPTLK 150 LFKPGQEAVK 160 YQGPRDFQTL 170 ENWMLQTLNE 180 EPVTPEPEVE 190 PPSAPELKQG 200 LYELSASNFE 210 LHVAQGDHFI 220 KFFAPWCGHC 230 KALAPTWEQL 240 ALGLEHSETV 250 KIGKVDCTQH 260 YELCSGNQVR 270 GYPTLLWFRD 280 GKKVDQYKGK 290 RDLESLREYV 300 ESQLQRTETG 310 ATETVTPSEA 320 PVLAAEPEAD 330 KGTVLALTEN 340 NFDDTIAEGI 350 TFIKFYAPWC 360 GHCKTLAPTW 370 EELSKKEFPG 380 LAGVKIAEVD 390 CTAERNICSK 400 YSVRGYPTLL 410 LFRGGKKVSE 420 HSGGRDLDSL 430 HRFVLSQAKD EL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0043202 lysosomal lumen
Molecular Function GO:0003756 protein disulfide isomerase activity
Molecular Function GO:0015035 protein-disulfide reductase activity
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0006457 protein folding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.