Search Results

Overview

Uniprot IDQ8NC96
Protein NameAdaptin ear-binding coat-associated protein 1
Gene NameNECAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
148 QEMDARPKLDLGFKE
169 CIGNITNKKGGASKP
170 IGNITNKKGGASKPR

Function

Involved in endocytosis

Protein Sequence

10 MATELEYESV 20 LCVKPDVSVY 30 RIPPRASNRG 40 YRASDWKLDQ 50 PDWTGRLRIT 60 SKGKTAYIKL 70 EDKVSGELFA 80 QAPVEQYPGI 90 AVETVTDSSR 100 YFVIRIQDGT 110 GRSAFIGIGF 120 TDRGDAFDFN 130 VSLQDHFKWV 140 KQESEISKES 150 QEMDARPKLD 160 LGFKEGQTIK 170 LCIGNITNKK 180 GGASKPRTAR 190 GGGLSLLPPP 200 PGGKVTIPPP 210 SSSVAISNHV 220 TPPPIPKSNH 230 GGSDADILLD 240 LDSPAPVTTP 250 APTPVSVSND 260 LWGDFSTASS 270 SVPNQAPQPS NWVQF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030125 clathrin vesicle coat
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098793 presynapse
Biological Process GO:0140238 presynaptic endocytosis
Biological Process GO:0015031 protein transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.