Search Results
Overview
| Uniprot ID | Q8NCA5 |
|---|---|
| Protein Name | Protein FAM98A |
| Gene Name | FAM98A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 296 | KTACAINKVLMGRVP |
| 324 | PEMPPWQKRQDGPQQ |
Function
Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity)
Protein Sequence
10
MECDLMETDI
20
LESLEDLGYK
30
GPLLEDGALS
40
QAVSAGASSP
50
EFTKLCAWLV
60
SELRVLCKLE
70
ENVQATNSPS
80
EAEEFQLEVS
90
GLLGEMNCPY
100
LSLTSGDVTK
110
RLLIQKNCLL
120
LLTYLISELE
130
AARMLCVNAP
140
PKKAQEGGGS
150
EVFQELKGIC
160
IALGMSKPPA
170
NITMFQFFSG
180
IEKKLKETLA
190
KVPPNHVGKP
200
LLKKPMGPAH
210
WEKIEAINQA
220
IANEYEVRRK
230
LLIKRLDVTV
240
QSFGWSDRAK
250
SQTEKLAKVY
260
QPKRSVLSPK
270
TTISVAHLLA
280
ARQDLSKILR
290
TSSGSIREKT
300
ACAINKVLMG
310
RVPDRGGRPN
320
EIEPPPPEMP
330
PWQKRQDGPQ
340
QQTGGRGGGR
350
GGYEHSSYGG
360
RGGHEQGGGR
370
GGRGGYDHGG
380
RGGGRGNKHQ
390
GGWTDGGSGG
400
GGGYQDGGYR
410
DSGFQPGGYH
420
GGHSSGGYQG
430
GGYGGFQTSS
440
SYTGSGYQGG
450
GYQQDNRYQD
460
GGHHGDRGGG
470
RGGRGGRGGR
480
GGRAGQGGGW
490
GGRGSQNYHQ
500
GGQFEQHFQH
510
GGYQYNHSGF
GQGRHYTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0072669 | tRNA-splicing ligase complex |
| Molecular Function | GO:0008276 | protein methyltransferase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0006479 | protein methylation |
| Biological Process | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.