Search Results
Overview
| Uniprot ID | Q8NCD3 |
|---|---|
| Protein Name | Holliday junction recognition protein |
| Gene Name | HJURP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 369 | VNRPQIHKLDPSWKE |
Function
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions
Protein Sequence
10
MLGTLRAMEG
20
EDVEDDQLLQ
30
KLRASRRRFQ
40
RRMQRLIEKY
50
NQPFEDTPVV
60
QMATLTYETP
70
QGLRIWGGRL
80
IKERNEGEIQ
90
DSSMKPADRT
100
DGSVQAAAWG
110
PELPSHRTVL
120
GADSKSGEVD
130
ATSDQEESVA
140
WALAPAVPQS
150
PLKNELRRKY
160
LTQVDILLQG
170
AEYFECAGNR
180
AGRDVRVTPL
190
PSLASPAVPA
200
PGYCSRISRK
210
SPGDPAKPAS
220
SPREWDPLHP
230
SSTDMALVPR
240
NDSLSLQETS
250
SSSFLSSQPF
260
EDDDICNVTI
270
SDLYAGMLHS
280
MSRLLSTKPS
290
SIISTKTFIM
300
QNWNSRRRHR
310
YKSRMNKTYC
320
KGARRSQRSS
330
KENFIPCSEP
340
VKGTGALRDC
350
KNVLDVSCRK
360
TGLKLEKAFL
370
EVNRPQIHKL
380
DPSWKERKVT
390
PSKYSSLIYF
400
DSSATYNLDE
410
ENRFRTLKWL
420
ISPVKIVSRP
430
TIRQGHGENR
440
QREIEIRFDQ
450
LHREYCLSPR
460
NQPRRMCLPD
470
SWAMNMYRGG
480
PASPGGLQGL
490
ETRRLSLPSS
500
KAKAKSLSEA
510
FENLGKRSLE
520
AGRCLPKSDS
530
SSSLPKTNPT
540
HSATRPQQTS
550
DLHVQGNSSG
560
IFRKSVSPSK
570
TLSVPDKEVP
580
GHGRNRYDEI
590
KEEFDKLHQK
600
YCLKSPGQMT
610
VPLCIGVSTD
620
KASMEVRYQT
630
EGFLGKLNPD
640
PHFQGFQKLP
650
SSPLGCRKSL
660
LGSTAIEAPS
670
STCVARAITR
680
DGTRDHQFPA
690
KRPRLSEPQG
700
SGRQGNSLGA
710
SDGVDNTVRP
720
GDQGSSSQPN
730
SEERGENTSY
740
RMEEKSDFML
EKLETKSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000775 | chromosome, centromeric region |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0034080 | CENP-A containing chromatin assembly |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0051101 | regulation of DNA binding |
| Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
Reference
PMID: N/A