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Overview

Uniprot ID	Q8NCF5
Protein Name	NFATC2-interacting protein
Gene Name	NFATC2IP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
129	LVPVYSGKVKSSLRL
131	PVYSGKVKSSLRLIP
218	THTRALKKLSEVNKR
224	KKLSEVNKRLQDLRS

Function

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity)

Protein Sequence

10 MAEPVGKRGR 20 WSGGSGAGRG 30 GRGGWGGRGR 40 RPRAQRSPSR 50 GTLDVVSVDL 60 VTDSDEEILE 70 VATARGAADE 80 VEVEPPEPPG 90 PVASRDNSNS 100 DSEGEDRRPA 110 GPPREPVRRR 120 RRLVLDPGEA 130 PLVPVYSGKV 140 KSSLRLIPDD 150 LSLLKLYPPG 160 DEEEAELADS 170 SGLYHEGSPS 180 PGSPWKTKLR 190 TKDKEEKKKT 200 EFLDLDNSPL 210 SPPSPRTKSR 220 THTRALKKLS 230 EVNKRLQDLR 240 SCLSPKPPQG 250 QEQQGQEDEV 260 VLVEGPTLPE 270 TPRLFPLKIR 280 CRADLVRLPL 290 RMSEPLQSVV 300 DHMATHLGVS 310 PSRILLLFGE 320 TELSPTATPR 330 TLKLGVADII 340 DCVVLTSSPE 350 ATETSQQLQL 360 RVQGKEKHQT 370 LEVSLSRDSP 380 LKTLMSHYEE 390 AMGLSGRKLS 400 FFFDGTKLSG 410 RELPADLGME SGDLIEVWG

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Biological Process	GO:0016925	protein sumoylation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.