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Overview

Uniprot ID	Q8NCN5
Protein Name	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
Gene Name	PDPR
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
100	RHLTIEQKMADYSNK

Function

Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine

Protein Sequence

10 MMFYRLLSIV 20 GRQRASPGWQ 30 NWSSARNSTS 40 AAEARSMALP 50 TQAQVVICGG 60 GITGTSVAYH 70 LSKMGWKDIV 80 LLEQGRLAAG 90 STRFCAGILS 100 TARHLTIEQK 110 MADYSNKLYY 120 QLEQETGIQT 130 GYTRTGSIFL 140 AQTQDRLISL 150 KRINAGLNVI 160 GIPSEIISPK 170 KVAELHHLLN 180 VHDLVGAMHV 190 PEDAVVSSAD 200 VALALASAAS 210 QNGVQIYDRT 220 SVLHVMVKKG 230 QVTGVETDKG 240 QIECQYFVNC 250 AGQWAYELGL 260 SNEEPVSIPL 270 HACEHFYLLT 280 RPLETPLQSS 290 TPTIVDADGR 300 IYIRNWQGGI 310 LSGGFEKNPK 320 PIFTEGKNQL 330 EIQNLQEDWD 340 HFEPLLSSLL 350 RRMPELETLE 360 IMKLVNCPET 370 FTPDMRCIMG 380 ESPAVQGYFV 390 LAGMNSAGLS 400 FGGGAGKYLA 410 EWMVHGYPSE 420 NVWELDLKRF 430 GALQSSRTFL 440 RHRVMEVMPL 450 MYDLKVPRWD 460 FQTGRQLRTS 470 PLYDRLDAQG 480 ARWMEKHGFE 490 RPKYFVPPDK 500 DLLALEQSKT 510 FYKPDWFDIV 520 ESEVKCCKEA 530 VCVIDMSSFT 540 KFEITSTGDQ 550 ALEVLQYLFS 560 NDLDVPVGHI 570 VHTGMLNEGG 580 GYENDCSIAR 590 LNKRSFFMIS 600 PTDQQVHCWA 610 WLKKHMPKDS 620 NLLLEDVTWK 630 YTALNLIGPR 640 AVDVLSELSY 650 APMTPDHFPS 660 LFCKEMSVGY 670 ANGIRVMSMT 680 HTGEPGFMLY 690 IPIEYALHVY 700 NEVMSVGQKY 710 GIRNAGYYAL 720 RSLRIEKFFA 730 FWGQDINNLT 740 TPLECGRESR 750 VKLEKGMDFI 760 GRDALLQQKQ 770 NGVYKRLTMF 780 ILDDHDSDLD 790 LWPWWGEPIY 800 RNGQYVGKTT 810 SSAYSYSLER 820 HVCLGFVHNF 830 SEDTGEEQVV 840 TADFINRGEY 850 EIDIAGYRFQ 860 AKAKLYPVAS 870 LFTQKRRKDD MELSDLHGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Biological Process	GO:0140176	positive regulation of pyruvate decarboxylation to acetyl-CoA

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.