Search Results

Overview

Uniprot ID	Q8NCW5
Protein Name	NAD(P)H-hydrate epimerase
Gene Name	NAXE
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
148	YYPKRPNKPLFTALV
246	ISLTAPKKSATQFTG

Function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:27616477). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382)

Protein Sequence

10 MSRLRALLGL 20 GLLVAGSRVP 30 RIKSQTIACR 40 SGPTWWGPQR 50 LNSGGRWDSE 60 VMASTVVKYL 70 SQEEAQAVDQ 80 ELFNEYQFSV 90 DQLMELAGLS 100 CATAIAKAYP 110 PTSMSRSPPT 120 VLVICGPGNN 130 GGDGLVCARH 140 LKLFGYEPTI 150 YYPKRPNKPL 160 FTALVTQCQK 170 MDIPFLGEMP 180 AEPMTIDELY 190 ELVVDAIFGF 200 SFKGDVREPF 210 HSILSVLKGL 220 TVPIASIDIP 230 SGWDVEKGNA 240 GGIQPDLLIS 250 LTAPKKSATQ 260 FTGRYHYLGG 270 RFVPPALEKK 280 YQLNLPPYPD TECVYRLQ

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0031580	membrane raft distribution
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0052856	NAD(P)HX epimerase activity
Molecular Function	GO:0000166	nucleotide binding
Biological Process	GO:0006869	lipid transport
Biological Process	GO:0110051	metabolite repair
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0046496	nicotinamide nucleotide metabolic process
Biological Process	GO:0010874	regulation of cholesterol efflux
Biological Process	GO:0002040	sprouting angiogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.