Search Results

Overview

Uniprot IDQ8ND56
Protein NameProtein LSM14 homolog A
Gene NameLSM14A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
174 TQDTRSLKTQLSQGR
321 FHNKLKLKEDKLEKQ
324 KLKLKEDKLEKQEKP

Function

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800)

Protein Sequence

10 MSGGTPYIGS 20 KISLISKAEI 30 RYEGILYTID 40 TENSTVALAK 50 VRSFGTEDRP 60 TDRPIPPRDE 70 VFEYIIFRGS 80 DIKDLTVCEP 90 PKPQCSLPQD 100 PAIVQSSLGS 110 STSSFQSMGS 120 YGPFGRMPTY 130 SQFSPSSLVG 140 QQFGAVGVAG 150 SSLTSFGTET 160 SNSGTLPQSS 170 AVGSAFTQDT 180 RSLKTQLSQG 190 RSSPQLDPLR 200 KSPTMEQAVQ 210 TASAHLPAPA 220 AVGRRSPVST 230 RPLPSASQKA 240 GENQEHRRAE 250 VHKVSRPENE 260 QLRNDNKRQV 270 APGAPSAPRR 280 GRGGHRGGRG 290 RFGIRRDGPM 300 KFEKDFDFES 310 ANAQFNKEEI 320 DREFHNKLKL 330 KEDKLEKQEK 340 PVNGEDKGDS 350 GVDTQNSEGN 360 ADEEDPLGPN 370 CYYDKTKSFF 380 DNISCDDNRE 390 RRPTWAEERR 400 LNAETFGIPL 410 RPNRGRGGYR 420 GRGGLGFRGG 430 RGRGGGRGGT 440 FTAPRGFRGG 450 FRGGRGGREF 460 ADFEYRKTTA FGP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0000932 P-body
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003727 single-stranded RNA binding
Biological Process GO:0090307 mitotic spindle assembly
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0033962 P-body assembly
Biological Process GO:0034063 stress granule assembly

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.