Search Results
Overview
| Uniprot ID | Q8ND76 |
|---|---|
| Protein Name | Cyclin-Y |
| Gene Name | CCNY |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 82 | TDVREKRKSLFINHH |
Function
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription
Protein Sequence
10
MGNTTSCCVS
20
SSPKLRRNAH
30
SRLESYRPDT
40
DLSREDTGCN
50
LQHISDRENI
60
DDLNMEFNPS
70
DHPRASTIFL
80
SKSQTDVREK
90
RKSLFINHHP
100
PGQIARKYSS
110
CSTIFLDDST
120
VSQPNLKYTI
130
KCVALAIYYH
140
IKNRDPDGRM
150
LLDIFDENLH
160
PLSKSEVPPD
170
YDKHNPEQKQ
180
IYRFVRTLFS
190
AAQLTAECAI
200
VTLVYLERLL
210
TYAEIDICPA
220
NWKRIVLGAI
230
LLASKVWDDQ
240
AVWNVDYCQI
250
LKDITVEDMN
260
ELERQFLELL
270
QFNINVPSSV
280
YAKYYFDLRS
290
LAEANNLSFP
300
LEPLSRERAH
310
KLEAISRLCE
320
DKYKDLRRSA
330
RKRSASADNL
340
TLPRWSPAII
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex |
| Biological Process | GO:0016055 | Wnt signaling pathway |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity |
| Molecular Function | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process | GO:0060828 | regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.