Search Results

Overview

Uniprot IDQ8ND82
Protein NameZinc finger protein 280C
Gene NameZNF280C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
113 PRFHLVSKSSQSSVT
167 AIFREGMKNTSYVLK
174 KNTSYVLKHPSTSKV
180 LKHPSTSKVNSVTPK
188 VNSVTPKKPKTSEDV
564 ASRSKTSKLHATTST
574 ATTSTASKVNTSKPR
668 SHSNHPGKRFCIFKK

Function

May function as a transcription factor

Protein Sequence

10 MDDDKPFQPK 20 NISKMAELFM 30 ECEEEELEPW 40 QKKVEETQDE 50 DDDELIFVGE 60 ISSSKPAISN 70 ILNRGHSSSS 80 SKGIKSEPHS 90 PGIPEIFRTA 100 SQRCRDPPSN 110 PVAASPRFHL 120 VSKSSQSSVT 130 VENASKPDFT 140 KNSQVGSDNS 150 SILLFDSTQE 160 SLPPSQDIPA 170 IFREGMKNTS 180 YVLKHPSTSK 190 VNSVTPKKPK 200 TSEDVPQINP 210 STSLPLIGSP 220 PVTSSQVMLS 230 KGTNTSSPYD 240 AGADYLRACP 250 KCNVQFNLLD 260 PLKYHMKHCC 270 PDMITKFLGV 280 IVKSERPCDE 290 DKTDSETGKL 300 IMLVNEFYYG 310 RHEGVTEKEP 320 KTYTTFKCFS 330 CSKVLKNNIR 340 FMNHMKHHLE 350 LEKQNNESWE 360 NHTTCQHCYR 370 QYPTPFQLQC 380 HIESTHTPHE 390 FSTICKICEL 400 SFETEHILLQ 410 HMKDTHKPGE 420 MPYVCQVCQF 430 RSSTFSDVEA 440 HFRAAHENTK 450 NLLCPFCLKV 460 SKMATPYMNH 470 YMKHQKKGVH 480 RCPKCRLQFL 490 TSKEKAEHKA 500 QHRTFIKPKE 510 LEGLPPGAKV 520 TIRASLGPLQ 530 SKLPTAPFGC 540 APGTSFLQVT 550 PPTSQNTTAR 560 NPRKSNASRS 570 KTSKLHATTS 580 TASKVNTSKP 590 RGRIAKSKAK 600 PSYKQKRQRN 610 RKNKMSLALK 620 NIRCRRGIHK 630 CIECHSKIKD 640 FASHFSIYIH 650 CSFCKYNTNC 660 NKAFVNHMMS 670 SHSNHPGKRF 680 CIFKKHSGTL 690 RGITLVCLKC 700 DFLADSSGLD 710 RMAKHLSQRK 720 THTCQVIIEN 730 VSKSTSTSEP TTGCSLK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.