Search Results
Overview
| Uniprot ID | Q8NDD1 |
|---|---|
| Protein Name | 40S small subunit processome assembly factor 1 |
| Gene Name | FSAF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | VEFHSNKKRKLTPDH |
| 187 | ITGYGKGKERILEQE |
| 239 | AQETDIFKKKKRKGQ |
| 270 | GRIGQVGKFKNGTLI |
| 272 | IGQVGKFKNGTLILS |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state
Protein Sequence
10
MRVDSSADPT
20
MSQEQGPGSS
30
TPPSSPTLLD
40
ALLQNLYDFG
50
GTEGETEQKK
60
IIKKRENKKR
70
DVMASAALAA
80
EPSPLPGSLI
90
RGQRKSASSF
100
FKELREERHC
110
APSGTPTGPE
120
ILAAAVPPSS
130
LKNNREQVEV
140
VEFHSNKKRK
150
LTPDHNKNTK
160
QANPSVLERD
170
VDTQEFNLEK
180
ARLEVHRFGI
190
TGYGKGKERI
200
LEQERAIMLG
210
AKPPKKSYVN
220
YKVLQEQIKE
230
KKAAKEEEKR
240
LAQETDIFKK
250
KKRKGQEDRK
260
SKKKSAPSIL
270
SNGRIGQVGK
280
FKNGTLILSP
290
VDIKKINSSR
VAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0032040 | small-subunit processome |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
Reference
PMID: N/A