Search Results

Overview

Uniprot IDQ8NDI1
Protein NameEH domain-binding protein 1
Gene NameEHBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1008 RNPVVFSKDSTVRKT
400 TERRVKRKAPAPPVL

Function

May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity)

Protein Sequence

10 MASVWKRLQR 20 VGKHASKFQF 30 VASYQELMVE 40 CTKKWQPDKL 50 VVVWTRRSRR 60 KSSKAHSWQP 70 GIKNPYRGVV 80 VWPVPENIEI 90 TVTLFKDPHA 100 EEFEDKEWTF 110 VIENESPSGR 120 RKALATSSIN 130 MKQYASPMPT 140 QTDVKLKFKP 150 LSKKVVSAAL 160 QFSLSCIFLR 170 EGKATDEDMQ 180 SLASLMSMKQ 190 ADIGNLDDFE 200 EDNEDDDENR 210 VNQEEKAAKI 220 TEIVNQLNAL 230 SSLDEDQDDC 240 IKQANMRSAK 250 SASSSEELIN 260 KLNFLDEAEK 270 DLATVNSNPF 280 DDPDAAELNP 290 FGDPDSEEPI 300 TETASPRKTE 310 DSFYNNSYNP 320 FKEVQTPQYL 330 NPFDEPEAFV 340 TIKDSPPQST 350 KRKNIRPVDM 360 SKYLYADSSK 370 TEEEELDESN 380 PFYEPKSTPP 390 PNNLVNPVQE 400 LETERRVKRK 410 APAPPVLSPK 420 TGVLNENTVS 430 AGKDLSTSPK 440 PSPIPSPVLG 450 RKPNASQSLL 460 VWCKEVTKNY 470 RGVKITNFTT 480 SWRNGLSFCA 490 ILHHFRPDLI 500 DYKSLNPQDI 510 KENNKKAYDG 520 FASIGISRLL 530 EPSDMVLLAI 540 PDKLTVMTYL 550 YQIRAHFSGQ 560 ELNVVQIEEN 570 SSKSTYKVGN 580 YETDTNSSVD 590 QEKFYAELSD 600 LKREPELQQP 610 ISGAVDFLSQ 620 DDSVFVNDSG 630 VGESESEHQT 640 PDDHLSPSTA 650 SPYCRRTKSD 660 TEPQKSQQSS 670 GRTSGSDDPG 680 ICSNTDSTQA 690 QVLLGKKRLL 700 KAETLELSDL 710 YVSDKKKDMS 720 PPFICEETDE 730 QKLQTLDIGS 740 NLEKEKLENS 750 RSLECRSDPE 760 SPIKKTSLSP 770 TSKLGYSYSR 780 DLDLAKKKHA 790 SLRQTESDPD 800 ADRTTLNHAD 810 HSSKIVQHRL 820 LSRQEELKER 830 ARVLLEQARR 840 DAALKAGNKH 850 NTNTATPFCN 860 RQLSDQQDEE 870 RRRQLRERAR 880 QLIAEARSGV 890 KMSELPSYGE 900 MAAEKLKERS 910 KASGDENDNI 920 EIDTNEEIPE 930 GFVVGGGDEL 940 TNLENDLDTP 950 EQNSKLVDLK 960 LKKLLEVQPQ 970 VANSPSSAAQ 980 KAVTESSEQD 990 MKSGTEDLRT 1000 ERLQKTTERF 1010 RNPVVFSKDS 1020 TVRKTQLQSF 1030 SQYIENRPEM 1040 KRQRSIQEDT 1050 KKGNEEKAAI 1060 TETQRKPSED 1070 EVLNKGFKDT 1080 SQYVVGELAA 1090 LENEQKQIDT 1100 RAALVEKRLR 1110 YLMDTGRNTE 1120 EEEAMMQEWF 1130 MLVNKKNALI 1140 RRMNQLSLLE 1150 KEHDLERRYE 1160 LLNRELRAML 1170 AIEDWQKTEA 1180 QKRREQLLLD 1190 ELVALVNKRD 1200 ALVRDLDAQE 1210 KQAEEEDEHL 1220 ERTLEQNKGK 1230 MAKKEEKCVL Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0032456 endocytic recycling
Biological Process GO:0006897 endocytosis
Biological Process GO:0015031 protein transport
Cellular Component GO:0005768 endosome
Cellular Component GO:0005886 plasma membrane

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.