Search Results

Overview

Uniprot IDQ8NDQ6
Protein NameZinc finger protein 540
Gene NameZNF540
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
207 YQLTLHQKIHTGEKS
213 QKIHTGEKSCKCEKC
216 HTGEKSCKCEKCGKV

Function

May act as a transcriptional repressor

Protein Sequence

10 MAHALVTFRD 20 VAIDFSQKEW 30 ECLDTTQRKL 40 YRDVMLENYN 50 NLVSLGYSGS 60 KPDVITLLEQ 70 GKEPCVVARD 80 VTGRQCPGLL 90 SRHKTKKLSS 100 EKDIHEISLS 110 KESIIEKSKT 120 LRLKGSIFRN 130 EWQNKSEFEG 140 QQGLKERSIS 150 QKKIVSKKMS 160 TDRKRPSFTL 170 NQRIHNSEKS 180 CDSHLVQHGK 190 IDSDVKHDCK 200 ECGSTFNNVY 210 QLTLHQKIHT 220 GEKSCKCEKC 230 GKVFSHSYQL 240 TLHQRFHTGE 250 KPYECQECGK 260 TFTLYPQLNR 270 HQKIHTGKKP 280 YMCKKCDKGF 290 FSRLELTQHK 300 RIHTGKKSYE 310 CKECGKVFQL 320 IFYFKEHERI 330 HTGKKPYECK 340 ECGKAFSVCG 350 QLTRHQKIHT 360 GVKPYECKEC 370 GKTFRLSFYL 380 TEHRRTHAGK 390 KPYECKECGK 400 SFNVRGQLNR 410 HKTIHTGIKP 420 FACKVCEKAF 430 SYSGDLRVHS 440 RIHTGEKPYE 450 CKECGKAFML 460 RSVLTEHQRL 470 HTGVKPYECK 480 ECGKTFRVRS 490 QISLHKKIHT 500 DVKPYKCVRC 510 GKTFRFGFYL 520 TEHQRIHTGE 530 KPYKCKECGK 540 AFIRRGNLKE 550 HLKIHSGLKP 560 YDCKECGKSF 570 SRRGQFTEHQ 580 KIHTGVKPYK 590 CKECGKAFSR 600 SVDLRIHQRI 610 HTGEKPYECK 620 QCGKAFRLNS 630 HLTEHQRIHT 640 GEKPYECKVC 650 RKAFRQYSHL 660 YQHQKTHNVI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000900 mRNA regulatory element binding translation repressor activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.