Search Results

Overview

Uniprot IDQ8NDX5
Protein NamePolyhomeotic-like protein 3
Gene NamePHC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
222 NLTLRSQKLGVLSSS
256 KTTVTSSKISQRDPS
733 LIEQPVKKRPLLDNQ
818 RYNVSCSKKFALSRW
819 YNVSCSKKFALSRWN

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility

Protein Sequence

10 MDTEPNPGTS 20 SVSTTTSSTT 30 TTTITTSSSR 40 MQQPQISVYS 50 GSDRHAVQVI 60 QQALHRPPSS 70 AAQYLQQMYA 80 AQQQHLMLHT 90 AALQQQHLSS 100 SQLQSLAAVQ 110 ASLSSGRPST 120 SPTGSVTQQS 130 SMSQTSINLS 140 TSPTPAQLIS 150 RSQASSSTSG 160 SITQQTMLLG 170 STSPTLTASQ 180 AQMYLRAQML 190 IFTPATTVAA 200 VQSDIPVVSS 210 SSSSSCQSAA 220 TQVQNLTLRS 230 QKLGVLSSSQ 240 NGPPKSTSQT 250 QSLTICHNKT 260 TVTSSKISQR 270 DPSPESNKKG 280 ESPSLESRST 290 AVTRTSSIHQ 300 LIAPASYSPI 310 QPHSLIKHQQ 320 IPLHSPPSKV 330 SHHQLILQQQ 340 QQQIQPITLQ 350 NSTQDPPPSQ 360 HCIPLQNHGL 370 PPAPSNAQSQ 380 HCSPIQSHPS 390 PLTVSPNQSQ 400 SAQQSVVVSP 410 PPPHSPSQSP 420 TIIIHPQALI 430 QPHPLVSSAL 440 QPGPNLQQST 450 ANQVQATAQL 460 NLPSHLPLPA 470 SPVVHIGPVQ 480 QSALVSPGQQ 490 IVSPSHQQYS 500 SLQSSPIPIA 510 SPPQMSTSPP 520 AQIPPLPLQS 530 MQSLQVQPEI 540 LSQGQVLVQN 550 ALVSEEELPA 560 AEALVQLPFQ 570 TLPPPQTVAV 580 NLQVQPPAPV 590 DPPVVYQVED 600 VCEEEMPEES 610 DECVRMDRTP 620 PPPTLSPAAI 630 TVGRGEDLTS 640 EHPLLEQVEL 650 PAVASVSASV 660 IKSPSDPSHV 670 SVPPPPLLLP 680 AATTRSNSTS 690 MHSSIPSIEN 700 KPPQAIVKPQ 710 ILTHVIEGFV 720 IQEGLEPFPV 730 SRSSLLIEQP 740 VKKRPLLDNQ 750 VINSVCVQPE 760 LQNNTKHADN 770 SSDTEMEDMI 780 AEETLEEMDS 790 ELLKCEFCGK 800 MGYANEFLRS 810 KRFCTMSCAK 820 RYNVSCSKKF 830 ALSRWNRKPD 840 NQSLGHRGRR 850 PSGPDGAARE 860 HILRQLPITY 870 PSAEEDLASH 880 EDSVPSAMTT 890 RLRRQSERER 900 ERELRDVRIR 910 KMPENSDLLP 920 VAQTEPSIWT 930 VDDVWAFIHS 940 LPGCQDIADE 950 FRAQEIDGQA 960 LLLLKEDHLM 970 SAMNIKLGPA 980 LKICARINSL KES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031519 PcG protein complex
Cellular Component GO:0035102 PRC1 complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045892 negative regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.