Search Results
Overview
| Uniprot ID | Q8NE62 |
|---|---|
| Protein Name | Choline dehydrogenase, mitochondrial |
| Gene Name | CHDH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 169 | HCLPYFRKAQGHELG |
| 484 | ALAPFRGKELQPGSH |
Function
Catalyzes the dehydrogenation of choline to betaine aldehyde in the mitochondria (By similarity). Involved in mitochondrial autophagy after mitochondrial damage (PubMed:25483962)
Protein Sequence
10
MWCLLRGLGR
20
PGALARGALG
30
QQQSLGARAL
40
ASAGSESRDE
50
YSYVVVGAGS
60
AGCVLAGRLT
70
EDPAERVLLL
80
EAGPKDVLAG
90
SKRLSWKIHM
100
PAALVANLCD
110
DRYNWCYHTE
120
VQRGLDGRVL
130
YWPRGRVWGG
140
SSSLNAMVYV
150
RGHAEDYERW
160
QRQGARGWDY
170
AHCLPYFRKA
180
QGHELGASRY
190
RGADGPLRVS
200
RGKTNHPLHC
210
AFLEATQQAG
220
YPLTEDMNGF
230
QQEGFGWMDM
240
TIHEGKRWSA
250
ACAYLHPALS
260
RTNLKAEAET
270
LVSRVLFEGT
280
RAVGVEYVKN
290
GQSHRAYASK
300
EVILSGGAIN
310
SPQLLMLSGI
320
GNADDLKKLG
330
IPVVCHLPGV
340
GQNLQDHLEI
350
YIQQACTRPI
360
TLHSAQKPLR
370
KVCIGLEWLW
380
KFTGEGATAH
390
LETGGFIRSQ
400
PGVPHPDIQF
410
HFLPSQVIDH
420
GRVPTQQEAY
430
QVHVGPMRGT
440
SVGWLKLRSA
450
NPQDHPVIQP
460
NYLSTETDIE
470
DFRLCVKLTR
480
EIFAQEALAP
490
FRGKELQPGS
500
HIQSDKEIDA
510
FVRAKADSAY
520
HPSCTCKMGQ
530
PSDPTAVVDP
540
QTRVLGVENL
550
RVVDASIMPS
560
MVSGNLNAPT
570
IMIAEKAADI
580
IKGQPALWDK
590
DVPVYKPRTL
ATQR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008812 | choline dehydrogenase activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Biological Process | GO:0042426 | choline catabolic process |
| Biological Process | GO:0019285 | glycine betaine biosynthetic process from choline |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.