Search Results

Overview

Uniprot IDQ8NE71
Protein NameATP-binding cassette sub-family F member 1
Gene NameABCF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
163 PEKNRINKAVSEEQQ
174 EEQQPALKGKKGKEE
192 GKAKPQNKFAALDNE
255 DPYAHLSKKEKKKLK
342 VGPNGKGKTTLLKHI
39 KKDKKIKKTFFEELA
430 GAAAAEAKARRILAG
576 KQAEKQTKEALTRKQ
589 KQQKCRRKNQDEESQ
6 **MPKAPKQQPPEPE
85 DTRKGRRKKDVDDDG

Function

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis

Protein Sequence

10 MPKAPKQQPP 20 EPEWIGDGES 30 TSPSDKVVKK 40 GKKDKKIKKT 50 FFEELAVEDK 60 QAGEEEKVLK 70 EKEQQQQQQQ 80 QQQKKKRDTR 90 KGRRKKDVDD 100 DGEEKELMER 110 LKKLSVPTSD 120 EEDEVPAPKP 130 RGGKKTKGGN 140 VFAALIQDQS 150 EEEEEEEKHP 160 PKPAKPEKNR 170 INKAVSEEQQ 180 PALKGKKGKE 190 EKSKGKAKPQ 200 NKFAALDNEE 210 EDKEEEIIKE 220 KEPPKQGKEK 230 AKKAEQGSEE 240 EGEGEEEEEE 250 GGESKADDPY 260 AHLSKKEKKK 270 LKKQMEYERQ 280 VASLKAANAA 290 ENDFSVSQAE 300 MSSRQAMLEN 310 ASDIKLEKFS 320 ISAHGKELFV 330 NADLYIVAGR 340 RYGLVGPNGK 350 GKTTLLKHIA 360 NRALSIPPNI 370 DVLLCEQEVV 380 ADETPAVQAV 390 LRADTKRLKL 400 LEEERRLQGQ 410 LEQGDDTAAE 420 RLEKVYEELR 430 ATGAAAAEAK 440 ARRILAGLGF 450 DPEMQNRPTQ 460 KFSGGWRMRV 470 SLARALFMEP 480 TLLMLDEPTN 490 HLDLNAVIWL 500 NNYLQGWRKT 510 LLIVSHDQGF 520 LDDVCTDIIH 530 LDAQRLHYYR 540 GNYMTFKKMY 550 QQKQKELLKQ 560 YEKQEKKLKE 570 LKAGGKSTKQ 580 AEKQTKEALT 590 RKQQKCRRKN 600 QDEESQEAPE 610 LLKRPKEYTV 620 RFTFPDPPPL 630 SPPVLGLHGV 640 TFGYQGQKPL 650 FKNLDFGIDM 660 DSRICIVGPN 670 GVGKSTLLLL 680 LTGKLTPTHG 690 EMRKNHRLKI 700 GFFNQQYAEQ 710 LRMEETPTEY 720 LQRGFNLPYQ 730 DARKCLGRFG 740 LESHAHTIQI 750 CKLSGGQKAR 760 VVFAELACRE 770 PDVLILDEPT 780 NNLDIESIDA 790 LGEAINEYKG 800 AVIVVSHDAR 810 LITETNCQLW 820 VVEEQSVSQI 830 DGDFEDYKRE 840 VLEALGEVMV SRPRE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008494 translation activator activity
Molecular Function GO:0008135 translation factor activity, RNA binding
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0006412 translation
Biological Process GO:0006413 translational initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.