Search Results
Overview
| Uniprot ID | Q8NEB7 |
|---|---|
| Protein Name | Acrosin-binding protein |
| Gene Name | ACRBP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 449 | WCARLATKGCEDVRV |
Function
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation
Protein Sequence
10
MRKPAAGFLP
20
SLLKVLLLPL
30
APAAAQDSTQ
40
ASTPGSPLSP
50
TEYERFFALL
60
TPTWKAETTC
70
RLRATHGCRN
80
PTLVQLDQYE
90
NHGLVPDGAV
100
CSNLPYASWF
110
ESFCQFTHYR
120
CSNHVYYAKR
130
VLCSQPVSIL
140
SPNTLKEIEA
150
SAEVSPTTMT
160
SPISPHFTVT
170
ERQTFQPWPE
180
RLSNNVEELL
190
QSSLSLGGQE
200
QAPEHKQEQG
210
VEHRQEPTQE
220
HKQEEGQKQE
230
EQEEEQEEEG
240
KQEEGQGTKE
250
GREAVSQLQT
260
DSEPKFHSES
270
LSSNPSSFAP
280
RVREVESTPM
290
IMENIQELIR
300
SAQEIDEMNE
310
IYDENSYWRN
320
QNPGSLLQLP
330
HTEALLVLCY
340
SIVENTCIIT
350
PTAKAWKYME
360
EEILGFGKSV
370
CDSLGRRHMS
380
TCALCDFCSL
390
KLEQCHSEAS
400
LQRQQCDTSH
410
KTPFVSPLLA
420
SQSLSIGNQV
430
GSPESGRFYG
440
LDLYGGLHMD
450
FWCARLATKG
460
CEDVRVSGWL
470
QTEFLSFQDG
480
DFPTKICDTD
490
YIQYPNYCSF
500
KSQQCLMRNR
510
NRKVSRMRCL
520
QNETYSALSP
530
GKSEDVVLRW
540
SQEFSTLTLG
QFG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0002080 | acrosomal membrane |
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0001675 | acrosome assembly |
| Biological Process | GO:0009566 | fertilization |
| Biological Process | GO:0007286 | spermatid development |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.