Search Results
Overview
| Uniprot ID | Q8NEP3 |
|---|---|
| Protein Name | Dynein axonemal assembly factor 1 |
| Gene Name | DNAAF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 404 | EEPPVEAKREDGGPE |
| 90 | DRGPRMTKSSLQKLC |
Function
Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli
Protein Sequence
10
MHPEPSEPAT
20
GGAAELDCAQ
30
EPGVEESAGD
40
HGSAGRGGCK
50
EEINDPKEIC
60
VGSSDTSYHS
70
QQKQSGDNGS
80
GGHFAHPRED
90
REDRGPRMTK
100
SSLQKLCKQH
110
KLYITPALND
120
TLYLHFKGFD
130
RIENLEEYTG
140
LRCLWLQSNG
150
IQKIENLEAQ
160
TELRCLFLQM
170
NLLRKIENLE
180
PLQKLDALNL
190
SNNYIKTIEN
200
LSCLPVLNTL
210
QMAHNHLETV
220
EDIQHLQECL
230
RLCVLDLSHN
240
KLSDPEILSI
250
LESMPDLRVL
260
NLMGNPVIRQ
270
IPNYRRTVTV
280
RLKHLTYLDD
290
RPVFPKDRAC
300
AEAWARGGYA
310
AEKEERQQWE
320
SRERKKITDS
330
IEALAMIKQR
340
AEERKRQRES
350
QERGEMTSSD
360
DGENVPASAE
370
GKEEPPGDRE
380
TRQKMELFVK
390
ESFEAKDELC
400
PEKPSGEEPP
410
VEAKREDGGP
420
EPEGTLPAET
430
LLLSSPVEVK
440
GEDGDGEPEG
450
TLPAEAPPPP
460
PPVEVKGEDG
470
DQEPEGTLPA
480
ETLLLSPPVK
490
VKGEDGDREP
500
EGTLPAEAPP
510
PPPLGAAREE
520
PTPQAVATEG
530
VFVTELDGTR
540
TEDLETIRLE
550
TKETFCIDDL
560
PDLEDDDETG
570
KSLEDQNMCF
580
PKIEVISSLS
590
DDSDPELDYT
600
SLPVLENLPT
610
DTLSNIFAVS
620
KDTSKAARVP
630
FTDIFKKEAK
640
RDLEIRKQDT
650
KSPRPLIQEL
660
SDEDPSGQLL
670
MPPTCQRDAA
680
PLTSSGDRDS
690
DFLAASSPVP
700
TESAATPPET
710
CVGVAQPSQA
720
LPTWDLTAFP
APKAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0070840 | dynein complex binding |
| Biological Process | GO:0070286 | axonemal dynein complex assembly |
| Biological Process | GO:0035082 | axoneme assembly |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0003341 | cilium movement |
| Biological Process | GO:0071907 | determination of digestive tract left/right asymmetry |
| Biological Process | GO:0007368 | determination of left/right symmetry |
| Biological Process | GO:0071910 | determination of liver left/right asymmetry |
| Biological Process | GO:0035469 | determination of pancreatic left/right asymmetry |
| Biological Process | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry |
| Biological Process | GO:0001947 | heart looping |
| Biological Process | GO:0036159 | inner dynein arm assembly |
| Biological Process | GO:0060972 | left/right pattern formation |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0044458 | motile cilium assembly |
| Biological Process | GO:0036158 | outer dynein arm assembly |
| Biological Process | GO:0003356 | regulation of cilium beat frequency |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.