Search Results

Overview

Uniprot IDQ8NEZ4
Protein NameHistone-lysine N-methyltransferase 2C
Gene NameKMT2C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2398 ILQQQQQKKIAGRQE

Function

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332)

Protein Sequence

10 MSSEEDKSVE 20 QPQPPPPPPE 30 EPGAPAPSPA 40 AADKRPRGRP 50 RKDGASPFQR 60 ARKKPRSRGK 70 TAVEDEDSMD 80 GLETTETETI 90 VETEIKEQSA 100 EEDAEAEVDN 110 SKQLIPTLQR 120 SVSEESANSL 130 VSVGVEAKIS 140 EQLCAFCYCG 150 EKSSLGQGDL 160 KQFRITPGFI 170 LPWRNQPSNK 180 KDIDDNSNGT 190 YEKMQNSAPR 200 KQRGQRKERS 210 PQQNIVSCVS 220 VSTQTASDDQ 230 AGKLWDELSL 240 VGLPDAIDIQ 250 ALFDSTGTCW 260 AHHRCVEWSL 270 GVCQMEEPLL 280 VNVDKAVVSG 290 STERCAFCKH 300 LGATIKCCEE 310 KCTQMYHYPC 320 AAGAGTFQDF 330 SHIFLLCPEH 340 IDQAPERSKE 350 DANCAVCDSP 360 GDLLDQFFCT 370 TCGQHYHGMC 380 LDIAVTPLKR 390 AGWQCPECKV 400 CQNCKQSGED 410 SKMLVCDTCD 420 KGYHTFCLQP 430 VMKSVPTNGW 440 KCKNCRICIE 450 CGTRSSSQWH 460 HNCLICDNCY 470 QQQDNLCPFC 480 GKCYHPELQK 490 DMLHCNMCKR 500 WVHLECDKPT 510 DHELDTQLKE 520 EYICMYCKHL 530 GAEMDRLQPG 540 EEVEIAELTT 550 DYNNEMEVEG 560 PEDQMVFSEQ 570 AANKDVNGQE 580 STPGIVPDAV 590 QVHTEEQQKS 600 HPSESLDTDS 610 LLIAVSSQHT 620 VNTELEKQIS 630 NEVDSEDLKM 640 SSEVKHICGE 650 DQIEDKMEVT 660 ENIEVVTHQI 670 TVQQEQLQLL 680 EEPETVVSRE 690 ESRPPKLVME 700 SVTLPLETLV 710 SPHEESISLC 720 PEEQLVIERL 730 QGEKEQKENS 740 ELSTGLMDSE 750 MTPTIEGCVK 760 DVSYQGGKSI 770 KLSSETESSF 780 SSSADISKAD 790 VSSSPTPSSD 800 LPSHDMLHNY 810 PSALSSSAGN 820 IMPTTYISVT 830 PKIGMGKPAI 840 TKRKFSPGRP 850 RSKQGAWSTH 860 NTVSPPSWSP 870 DISEGREIFK 880 PRQLPGSAIW 890 SIKVGRGSGF 900 PGKRRPRGAG 910 LSGRGGRGRS 920 KLKSGIGAVV 930 LPGVSTADIS 940 SNKDDEENSM 950 HNTVVLFSSS 960 DKFTLNQDMC 970 VVCGSFGQGA 980 EGRLLACSQC 990 GQCYHPYCVS 1000 IKITKVVLSK 1010 GWRCLECTVC 1020 EACGKATDPG 1030 RLLLCDDCDI 1040 SYHTYCLDPP 1050 LQTVPKGGWK 1060 CKWCVWCRHC 1070 GATSAGLRCE 1080 WQNNYTQCAP 1090 CASLSSCPVC 1100 YRNYREEDLI 1110 LQCRQCDRWM 1120 HAVCQNLNTE 1130 EEVENVADIG 1140 FDCSMCRPYM 1150 PASNVPSSDC 1160 CESSLVAQIV 1170 TKVKELDPPK 1180 TYTQDGVCLT 1190 ESGMTQLQSL 1200 TVTVPRRKRS 1210 KPKLKLKIIN 1220 QNSVAVLQTP 1230 PDIQSEHSRD 1240 GEMDDSREGE 1250 LMDCDGKSES 1260 SPEREAVDDE 1270 TKGVEGTDGV 1280 KKRKRKPYRP 1290 GIGGFMVRQR 1300 SRTGQGKTKR 1310 SVIRKDSSGS 1320 ISEQLPCRDD 1330 GWSEQLPDTL 1340 VDESVSVTES 1350 TEKIKKRYRK 1360 RKNKLEETFP 1370 AYLQEAFFGK 1380 DLLDTSRQSK 1390 ISLDNLSEDG 1400 AQLLYKTNMN 1410 TGFLDPSLDP 1420 LLSSSSAPTK 1430 SGTHGPADDP 1440 LADISEVLNT 1450 DDDILGIISD 1460 DLAKSVDHSD 1470 IGPVTDDPSS 1480 LPQPNVNQSS 1490 RPLSEEQLDG 1500 ILSPELDKMV 1510 TDGAILGKLY 1520 KIPELGGKDV 1530 EDLFTAVLSP 1540 ANTQPTPLPQ 1550 PPPPTQLLPI 1560 HNQDAFSRMP 1570 LMNGLIGSSP 1580 HLPHNSLPPG 1590 SGLGTFSAIA 1600 QSSYPDARDK 1610 NSAFNPMASD 1620 PNNSWTSSAP 1630 TVEGENDTMS 1640 NAQRSTLKWE 1650 KEEALGEMAT 1660 VAPVLYTNIN 1670 FPNLKEEFPD 1680 WTTRVKQIAK 1690 LWRKASSQER 1700 APYVQKARDN 1710 RAALRINKVQ 1720 MSNDSMKRQQ 1730 QQDSIDPSSR 1740 IDSELFKDPL 1750 KQRESEHEQE 1760 WKFRQQMRQK 1770 SKQQAKIEAT 1780 QKLEQVKNEQ 1790 QQQQQQQFGS 1800 QHLLVQSGSD 1810 TPSSGIQSPL 1820 TPQPGNGNMS 1830 PAQSFHKELF 1840 TKQPPSTPTS 1850 TSSDDVFVKP 1860 QAPPPPPAPS 1870 RIPIQDSLSQ 1880 AQTSQPPSPQ 1890 VFSPGSSNSR 1900 PPSPMDPYAK 1910 MVGTPRPPPV 1920 GHSFSRRNSA 1930 APVENCTPLS 1940 SVSRPLQMNE 1950 TTANRPSPVR 1960 DLCSSSTTNN 1970 DPYAKPPDTP 1980 RPVMTDQFPK 1990 SLGLSRSPVV 2000 SEQTAKGPIA 2010 AGTSDHFTKP 2020 SPRADVFQRQ 2030 RIPDSYARPL 2040 LTPAPLDSGP 2050 GPFKTPMQPP 2060 PSSQDPYGSV 2070 SQASRRLSVD 2080 PYERPALTPR 2090 PIDNFSHNQS 2100 NDPYSQPPLT 2110 PHPAVNESFA 2120 HPSRAFSQPG 2130 TISRPTSQDP 2140 YSQPPGTPRP 2150 VVDSYSQSSG 2160 TARSNTDPYS 2170 QPPGTPRPTT 2180 VDPYSQQPQT 2190 PRPSTQTDLF 2200 VTPVTNQRHS 2210 DPYAHPPGTP 2220 RPGISVPYSQ 2230 PPATPRPRIS 2240 EGFTRSSMTR 2250 PVLMPNQDPF 2260 LQAAQNRGPA 2270 LPGPLVRPPD 2280 TCSQTPRPPG 2290 PGLSDTFSRV 2300 SPSAARDPYD 2310 QSPMTPRSQS 2320 DSFGTSQTAH 2330 DVADQPRPGS 2340 EGSFCASSNS 2350 PMHSQGQQFS 2360 GVSQLPGPVP 2370 TSGVTDTQNT 2380 VNMAQADTEK 2390 LRQRQKLREI 2400 ILQQQQQKKI 2410 AGRQEKGSQD 2420 SPAVPHPGPL 2430 QHWQPENVNQ 2440 AFTRPPPPYP 2450 GNIRSPVAPP 2460 LGPRYAVFPK 2470 DQRGPYPPDV 2480 ASMGMRPHGF 2490 RFGFPGGSHG 2500 TMPSQERFLV 2510 PPQQIQGSGV 2520 SPQLRRSVSV 2530 DMPRPLNNSQ 2540 MNNPVGLPQH 2550 FSPQSLPVQQ 2560 HNILGQAYIE 2570 LRHRAPDGRQ 2580 RLPFSAPPGS 2590 VVEASSNLRH 2600 GNFIPRPDFP 2610 GPRHTDPMRR 2620 PPQGLPNQLP 2630 VHPDLEQVPP 2640 SQQEQGHSVH 2650 SSSMVMRTLN 2660 HPLGGEFSEA 2670 PLSTSVPSET 2680 TSDNLQITTQ 2690 PSDGLEEKLD 2700 SDDPSVKELD 2710 VKDLEGVEVK 2720 DLDDEDLENL 2730 NLDTEDGKVV 2740 ELDTLDNLET 2750 NDPNLDDLLR 2760 SGEFDIIAYT 2770 DPELDMGDKK 2780 SMFNEELDLP 2790 IDDKLDNQCV 2800 SVEPKKKEQE 2810 NKTLVLSDKH 2820 SPQKKSTVTN 2830 EVKTEVLSPN 2840 SKVESKCETE 2850 KNDENKDNVD 2860 TPCSQASAHS 2870 DLNDGEKTSL 2880 HPCDPDLFEK 2890 RTNRETAGPS 2900 ANVIQASTQL 2910 PAQDVINSCG 2920 ITGSTPVLSS 2930 LLANEKSDNS 2940 DIRPSGSPPP 2950 PTLPASPSNH 2960 VSSLPPFIAP 2970 PGRVLDNAMN 2980 SNVTVVSRVN 2990 HVFSQGVQVN 3000 PGLIPGQSTV 3010 NHSLGTGKPA 3020 TQTGPQTSQS 3030 GTSSMSGPQQ 3040 LMIPQTLAQQ 3050 NRERPLLLEE 3060 QPLLLQDLLD 3070 QERQEQQQQR 3080 QMQAMIRQRS 3090 EPFFPNIDFD 3100 AITDPIMKAK 3110 MVALKGINKV 3120 MAQNNLGMPP 3130 MVMSRFPFMG 3140 QVVTGTQNSE 3150 GQNLGPQAIP 3160 QDGSITHQIS 3170 RPNPPNFGPG 3180 FVNDSQRKQY 3190 EEWLQETQQL 3200 LQMQQKYLEE 3210 QIGAHRKSKK 3220 ALSAKQRTAK 3230 KAGREFPEED 3240 AEQLKHVTEQ 3250 QSMVQKQLEQ 3260 IRKQQKEHAE 3270 LIEDYRIKQQ 3280 QQCAMAPPTM 3290 MPSVQPQPPL 3300 IPGATPPTMS 3310 QPTFPMVPQQ 3320 LQHQQHTTVI 3330 SGHTSPVRMP 3340 SLPGWQPNSA 3350 PAHLPLNPPR 3360 IQPPIAQLPI 3370 KTCTPAPGTV 3380 SNANPQSGPP 3390 PRVEFDDNNP 3400 FSESFQERER 3410 KERLREQQER 3420 QRIQLMQEVD 3430 RQRALQQRME 3440 MEQHGMVGSE 3450 ISSSRTSVSQ 3460 IPFYSSDLPC 3470 DFMQPLGPLQ 3480 QSPQHQQQMG 3490 QVLQQQNIQQ 3500 GSINSPSTQT 3510 FMQTNERRQV 3520 GPPSFVPDSP 3530 SIPVGSPNFS 3540 SVKQGHGNLS 3550 GTSFQQSPVR 3560 PSFTPALPAA 3570 PPVANSSLPC 3580 GQDSTITHGH 3590 SYPGSTQSLI 3600 QLYSDIIPEE 3610 KGKKKRTRKK 3620 KRDDDAESTK 3630 APSTPHSDIT 3640 APPTPGISET 3650 TSTPAVSTPS 3660 ELPQQADQES 3670 VEPVGPSTPN 3680 MAAGQLCTEL 3690 ENKLPNSDFS 3700 QATPNQQTYA 3710 NSEVDKLSME 3720 TPAKTEEIKL 3730 EKAETESCPG 3740 QEEPKLEEQN 3750 GSKVEGNAVA 3760 CPVSSAQSPP 3770 HSAGAPAAKG 3780 DSGNELLKHL 3790 LKNKKSSSLL 3800 NQKPEGSICS 3810 EDDCTKDNKL 3820 VEKQNPAEGL 3830 QTLGAQMQGG 3840 FGCGNQLPKT 3850 DGGSETKKQR 3860 SKRTQRTGEK 3870 AAPRSKKRKK 3880 DEEEKQAMYS 3890 STDTFTHLKQ 3900 QNNLSNPPTP 3910 PASLPPTPPP 3920 MACQKMANGF 3930 ATTEELAGKA 3940 GVLVSHEVTK 3950 TLGPKPFQLP 3960 FRPQDDLLAR 3970 ALAQGPKTVD 3980 VPASLPTPPH 3990 NNQEELRIQD 4000 HCGDRDTPDS 4010 FVPSSSPESV 4020 VGVEVSRYPD 4030 LSLVKEEPPE 4040 PVPSPIIPIL 4050 PSTAGKSSES 4060 RRNDIKTEPG 4070 TLYFASPFGP 4080 SPNGPRSGLI 4090 SVAITLHPTA 4100 AENISSVVAA 4110 FSDLLHVRIP 4120 NSYEVSSAPD 4130 VPSMGLVSSH 4140 RINPGLEYRQ 4150 HLLLRGPPPG 4160 SANPPRLVSS 4170 YRLKQPNVPF 4180 PPTSNGLSGY 4190 KDSSHGIAES 4200 AALRPQWCCH 4210 CKVVILGSGV 4220 RKSFKDLTLL 4230 NKDSRESTKR 4240 VEKDIVFCSN 4250 NCFILYSSTA 4260 QAKNSENKES 4270 IPSLPQSPMR 4280 ETPSKAFHQY 4290 SNNISTLDVH 4300 CLPQLPEKAS 4310 PPASPPIAFP 4320 PAFEAAQVEA 4330 KPDELKVTVK 4340 LKPRLRAVHG 4350 GFEDCRPLNK 4360 KWRGMKWKKW 4370 SIHIVIPKGT 4380 FKPPCEDEID 4390 EFLKKLGTSL 4400 KPDPVPKDYR 4410 KCCFCHEEGD 4420 GLTDGPARLL 4430 NLDLDLWVHL 4440 NCALWSTEVY 4450 ETQAGALINV 4460 ELALRRGLQM 4470 KCVFCHKTGA 4480 TSGCHRFRCT 4490 NIYHFTCAIK 4500 AQCMFFKDKT 4510 MLCPMHKPKG 4520 IHEQELSYFA 4530 VFRRVYVQRD 4540 EVRQIASIVQ 4550 RGERDHTFRV 4560 GSLIFHTIGQ 4570 LLPQQMQAFH 4580 SPKALFPVGY 4590 EASRLYWSTR 4600 YANRRCRYLC 4610 SIEEKDGRPV 4620 FVIRIVEQGH 4630 EDLVLSDISP 4640 KGVWDKILEP 4650 VACVRKKSEM 4660 LQLFPAYLKG 4670 EDLFGLTVSA 4680 VARIAESLPG 4690 VEACENYTFR 4700 YGRNPLMELP 4710 LAVNPTGCAR 4720 SEPKMSAHVK 4730 RFVLRPHTLN 4740 STSTSKSFQS 4750 TVTGELNAPY 4760 SKQFVHSKSS 4770 QYRKMKTEWK 4780 SNVYLARSRI 4790 QGLGLYAARD 4800 IEKHTMVIEY 4810 IGTIIRNEVA 4820 NRKEKLYESQ 4830 NRGVYMFRMD 4840 NDHVIDATLT 4850 GGPARYINHS 4860 CAPNCVAEVV 4870 TFERGHKIII 4880 SSSRRIQKGE 4890 ELCYDYKFDF 4900 EDDQHKIPCH 4910 CGAVNCRKWM N

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0035097 histone methyltransferase complex
Cellular Component GO:0044666 MLL3/4 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016746 acyltransferase activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042800 histone H3K4 methyltransferase activity
Molecular Function GO:0140945 histone H3K4 monomethyltransferase activity
Molecular Function GO:0042054 histone methyltransferase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032259 methylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

PMID: N/A