Overview
| Uniprot ID | Q8NF37 |
|---|
| Protein Name | Lysophosphatidylcholine acyltransferase 1 |
|---|
| Gene Name | LPCAT1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 221 |
RTCLITFKPGAFIPG |
Function
Exhibits acyltransferase activity (PubMed:18156367, PubMed:21498505). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:18156367, PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
Protein Sequence
10
MRLRGCGPRA
20
APASSAGASD
30
ARLLAPPGRN
40
PFVHELRLSA
50
LQKAQVALMT
60
LTLFPVRLLV
70
AAAMMLLAWP
80
LALVASLGSA
90
EKEPEQPPAL
100
WRKVVDFLLK
110
AIMRTMWFAG
120
GFHRVAVKGR
130
QALPTEAAIL
140
TLAPHSSYFD
150
AIPVTMTMSS
160
IVMKAESRDI
170
PIWGTLIQYI
180
RPVFVSRSDQ
190
DSRRKTVEEI
200
KRRAQSNGKW
210
PQIMIFPEGT
220
CTNRTCLITF
230
KPGAFIPGAP
240
VQPVVLRYPN
250
KLDTITWTWQ
260
GPGALEILWL
270
TLCQFHNQVE
280
IEFLPVYSPS
290
EEEKRNPALY
300
ASNVRRVMAE
310
ALGVSVTDYT
320
FEDCQLALAE
330
GQLRLPADTC
340
LLEFARLVRG
350
LGLKPEKLEK
360
DLDRYSERAR
370
MKGGEKIGIA
380
EFAASLEVPV
390
SDLLEDMFSL
400
FDESGSGEVD
410
LRECVVALSV
420
VCRPARTLDT
430
IQLAFKMYGA
440
QEDGSVGEGD
450
LSCILKTALG
460
VAELTVTDLF
470
RAIDQEEKGK
480
ITFADFHRFA
490
EMYPAFAEEY
500
LYPDQTHFES
510
CAETSPAPIP
520
NGFCADFSPE
530
NSDAGRKPVR
KKLD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035577 |
azurophil granule membrane |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003841 |
1-acylglycerol-3-phosphate O-acyltransferase activity |
| Molecular Function |
GO:0047184 |
1-acylglycerophosphocholine O-acyltransferase activity |
| Molecular Function |
GO:0047192 |
1-alkylglycerophosphocholine O-acetyltransferase activity |
| Molecular Function |
GO:0047191 |
1-alkylglycerophosphocholine O-acyltransferase activity |
| Molecular Function |
GO:0047144 |
2-acylglycerol-3-phosphate O-acyltransferase activity |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0042171 |
lysophosphatidic acid acyltransferase activity |
| Molecular Function |
GO:0047159 |
plasmalogen synthase activity |
| Biological Process |
GO:0006654 |
phosphatidic acid biosynthetic process |
| Biological Process |
GO:0036151 |
phosphatidylcholine acyl-chain remodeling |
| Biological Process |
GO:0036148 |
phosphatidylglycerol acyl-chain remodeling |
| Biological Process |
GO:0008654 |
phospholipid biosynthetic process |
Reference
PMID: N/A