Search Results

Overview

Uniprot IDQ8NF50
Protein NameDedicator of cytokinesis protein 8
Gene NameDOCK8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
894 SAAAVSSKLLQARVM

Function

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780)

Protein Sequence

10 MATLPSAERR 20 AFALKINRYS 30 SAEIRKQFTL 40 PPNLGQYHRQ 50 SISTSGFPSL 60 QLPQFYDPVE 70 PVDFEGLLMT 80 HLNSLDVQLA 90 QELGDFTDDD 100 LDVVFTPKEC 110 RTLQPSLPEE 120 GVELDPHVRD 130 CVQTYIREWL 140 IVNRKNQGSP 150 EICGFKKTGS 160 RKDFHKTLPK 170 QTFESETLEC 180 SEPAAQAGPR 190 HLNVLCDVSG 200 KGPVTACDFD 210 LRSLQPDKRL 220 ENLLQQVSAE 230 DFEKQNEEAR 240 RTNRQAELFA 250 LYPSVDEEDA 260 VEIRPVPECP 270 KEHLGNRILV 280 KLLTLKFEIE 290 IEPLFASIAL 300 YDVKERKKIS 310 ENFHCDLNSD 320 QFKGFLRAHT 330 PSVAASSQAR 340 SAVFSVTYPS 350 SDIYLVVKIE 360 KVLQQGEIGD 370 CAEPYTVIKE 380 SDGGKSKEKI 390 EKLKLQAESF 400 CQRLGKYRMP 410 FAWAPISLSS 420 FFNVSTLERE 430 VTDVDSVVGR 440 SSVGERRTLA 450 QSRRLSERAL 460 SLEENGVGSN 470 FKTSTLSVSS 480 FFKQEGDRLS 490 DEDLFKFLAD 500 YKRSSSLQRR 510 VKSIPGLLRL 520 EISTAPEIIN 530 CCLTPEMLPV 540 KPFPENRTRP 550 HKEILEFPTR 560 EVYVPHTVYR 570 NLLYVYPQRL 580 NFVNKLASAR 590 NITIKIQFMC 600 GEDASNAMPV 610 IFGKSSGPEF 620 LQEVYTAVTY 630 HNKSPDFYEE 640 VKIKLPAKLT 650 VNHHLLFTFY 660 HISCQQKQGA 670 SVETLLGYSW 680 LPILLNERLQ 690 TGSYCLPVAL 700 EKLPPNYSMH 710 SAEKVPLQNP 720 PIKWAEGHKG 730 VFNIEVQAVS 740 SVHTQDNHLE 750 KFFTLCHSLE 760 SQVTFPIRVL 770 DQKISEMALE 780 HELKLSIICL 790 NSSRLEPLVL 800 FLHLVLDKLF 810 QLSVQPMVIA 820 GQTANFSQFA 830 FESVVAIANS 840 LHNSKDLSKD 850 QHGRNCLLAS 860 YVHYVFRLPE 870 VQRDVPKSGA 880 PTALLDPRSY 890 HTYGRTSAAA 900 VSSKLLQARV 910 MSSSNPDLAG 920 THSAADEEVK 930 NIMSSKIADR 940 NCSRMSYYCS 950 GSSDAPSSPA 960 APRPASKKHF 970 HEELALQMVV 980 STGMVRETVF 990 KYAWFFFELL 1000 VKSMAQHVHN 1010 MDKRDSFRRT 1020 RFSDRFMDDI 1030 TTIVNVVTSE 1040 IAALLVKPQK 1050 ENEQAEKMNI 1060 SLAFFLYDLL 1070 SLMDRGFVFN 1080 LIRHYCSQLS 1090 AKLSNLPTLI 1100 SMRLEFLRIL 1110 CSHEHYLNLN 1120 LFFMNADTAP 1130 TSPCPSISSQ 1140 NSSSCSSFQD 1150 QKIASMFDLT 1160 SEYRQQHFLT 1170 GLLFTELAAA 1180 LDAEGEGISK 1190 VQRKAVSAIH 1200 SLLSSHDLDP 1210 RCVKPEVKVK 1220 IAALYLPLVG 1230 IILDALPQLC 1240 DFTVADTRRY 1250 RTSGSDEEQE 1260 GAGAINQNVA 1270 LAIAGNNFNL 1280 KTSGIVLSSL 1290 PYKQYNMLNA 1300 DTTRNLMICF 1310 LWIMKNADQS 1320 LIRKWIADLP 1330 STQLNRILDL 1340 LFICVLCFEY 1350 KGKQSSDKVS 1360 TQVLQKSRDV 1370 KARLEEALLR 1380 GEGARGEMMR 1390 RRAPGNDRFP 1400 GLNENLRWKK 1410 EQTHWRQANE 1420 KLDKTKAELD 1430 QEALISGNLA 1440 TEAHLIILDM 1450 QENIIQASSA 1460 LDCKDSLLGG 1470 VLRVLVNSLN 1480 CDQSTTYLTH 1490 CFATLRALIA 1500 KFGDLLFEEE 1510 VEQCFDLCHQ 1520 VLHHCSSSMD 1530 VTRSQACATL 1540 YLLMRFSFGA 1550 TSNFARVKMQ 1560 VTMSLASLVG 1570 RAPDFNEEHL 1580 RRSLRTILAY 1590 SEEDTAMQMT 1600 PFPTQVEELL 1610 CNLNSILYDT 1620 VKMREFQEDP 1630 EMLMDLMYRI 1640 AKSYQASPDL 1650 RLTWLQNMAE 1660 KHTKKKCYTE 1670 AAMCLVHAAA 1680 LVAEYLSMLE 1690 DHSYLPVGSV 1700 SFQNISSNVL 1710 EESVVSEDTL 1720 SPDEDGVCAG 1730 QYFTESGLVG 1740 LLEQAAELFS 1750 TGGLYETVNE 1760 VYKLVIPILE 1770 AHREFRKLTL 1780 THSKLQRAFD 1790 SIVNKDHKRM 1800 FGTYFRVGFF 1810 GSKFGDLDEQ 1820 EFVYKEPAIT 1830 KLPEISHRLE 1840 AFYGQCFGAE 1850 FVEVIKDSTP 1860 VDKTKLDPNK 1870 AYIQITFVEP 1880 YFDEYEMKDR 1890 VTYFEKNFNL 1900 RRFMYTTPFT 1910 LEGRPRGELH 1920 EQYRRNTVLT 1930 TMHAFPYIKT 1940 RISVIQKEEF 1950 VLTPIEVAIE 1960 DMKKKTLQLA 1970 VAINQEPPDA 1980 KMLQMVLQGS 1990 VGATVNQGPL 2000 EVAQVFLAEI 2010 PADPKLYRHH 2020 NKLRLCFKEF 2030 IMRCGEAVEK 2040 NKRLITADQR 2050 EYQQELKKNY 2060 NKLKENLRPM 2070 IERKIPELYK 2080 PIFRVESQKR 2090 DSFHRSSFRK CETQLSQGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031258 lamellipodium membrane
Cellular Component GO:0031256 leading edge membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:1990869 cellular response to chemokine
Biological Process GO:0061485 memory T cell proliferation
Biological Process GO:1903905 positive regulation of establishment of T cell polarity
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:2000406 positive regulation of T cell migration
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.