Overview
| Uniprot ID | Q8NF50 |
| Protein Name | Dedicator of cytokinesis protein 8 |
| Gene Name | DOCK8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 894 |
SAAAVSSKLLQARVM |
Function
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780)
Protein Sequence
10
MATLPSAERR
20
AFALKINRYS
30
SAEIRKQFTL
40
PPNLGQYHRQ
50
SISTSGFPSL
60
QLPQFYDPVE
70
PVDFEGLLMT
80
HLNSLDVQLA
90
QELGDFTDDD
100
LDVVFTPKEC
110
RTLQPSLPEE
120
GVELDPHVRD
130
CVQTYIREWL
140
IVNRKNQGSP
150
EICGFKKTGS
160
RKDFHKTLPK
170
QTFESETLEC
180
SEPAAQAGPR
190
HLNVLCDVSG
200
KGPVTACDFD
210
LRSLQPDKRL
220
ENLLQQVSAE
230
DFEKQNEEAR
240
RTNRQAELFA
250
LYPSVDEEDA
260
VEIRPVPECP
270
KEHLGNRILV
280
KLLTLKFEIE
290
IEPLFASIAL
300
YDVKERKKIS
310
ENFHCDLNSD
320
QFKGFLRAHT
330
PSVAASSQAR
340
SAVFSVTYPS
350
SDIYLVVKIE
360
KVLQQGEIGD
370
CAEPYTVIKE
380
SDGGKSKEKI
390
EKLKLQAESF
400
CQRLGKYRMP
410
FAWAPISLSS
420
FFNVSTLERE
430
VTDVDSVVGR
440
SSVGERRTLA
450
QSRRLSERAL
460
SLEENGVGSN
470
FKTSTLSVSS
480
FFKQEGDRLS
490
DEDLFKFLAD
500
YKRSSSLQRR
510
VKSIPGLLRL
520
EISTAPEIIN
530
CCLTPEMLPV
540
KPFPENRTRP
550
HKEILEFPTR
560
EVYVPHTVYR
570
NLLYVYPQRL
580
NFVNKLASAR
590
NITIKIQFMC
600
GEDASNAMPV
610
IFGKSSGPEF
620
LQEVYTAVTY
630
HNKSPDFYEE
640
VKIKLPAKLT
650
VNHHLLFTFY
660
HISCQQKQGA
670
SVETLLGYSW
680
LPILLNERLQ
690
TGSYCLPVAL
700
EKLPPNYSMH
710
SAEKVPLQNP
720
PIKWAEGHKG
730
VFNIEVQAVS
740
SVHTQDNHLE
750
KFFTLCHSLE
760
SQVTFPIRVL
770
DQKISEMALE
780
HELKLSIICL
790
NSSRLEPLVL
800
FLHLVLDKLF
810
QLSVQPMVIA
820
GQTANFSQFA
830
FESVVAIANS
840
LHNSKDLSKD
850
QHGRNCLLAS
860
YVHYVFRLPE
870
VQRDVPKSGA
880
PTALLDPRSY
890
HTYGRTSAAA
900
VSSKLLQARV
910
MSSSNPDLAG
920
THSAADEEVK
930
NIMSSKIADR
940
NCSRMSYYCS
950
GSSDAPSSPA
960
APRPASKKHF
970
HEELALQMVV
980
STGMVRETVF
990
KYAWFFFELL
1000
VKSMAQHVHN
1010
MDKRDSFRRT
1020
RFSDRFMDDI
1030
TTIVNVVTSE
1040
IAALLVKPQK
1050
ENEQAEKMNI
1060
SLAFFLYDLL
1070
SLMDRGFVFN
1080
LIRHYCSQLS
1090
AKLSNLPTLI
1100
SMRLEFLRIL
1110
CSHEHYLNLN
1120
LFFMNADTAP
1130
TSPCPSISSQ
1140
NSSSCSSFQD
1150
QKIASMFDLT
1160
SEYRQQHFLT
1170
GLLFTELAAA
1180
LDAEGEGISK
1190
VQRKAVSAIH
1200
SLLSSHDLDP
1210
RCVKPEVKVK
1220
IAALYLPLVG
1230
IILDALPQLC
1240
DFTVADTRRY
1250
RTSGSDEEQE
1260
GAGAINQNVA
1270
LAIAGNNFNL
1280
KTSGIVLSSL
1290
PYKQYNMLNA
1300
DTTRNLMICF
1310
LWIMKNADQS
1320
LIRKWIADLP
1330
STQLNRILDL
1340
LFICVLCFEY
1350
KGKQSSDKVS
1360
TQVLQKSRDV
1370
KARLEEALLR
1380
GEGARGEMMR
1390
RRAPGNDRFP
1400
GLNENLRWKK
1410
EQTHWRQANE
1420
KLDKTKAELD
1430
QEALISGNLA
1440
TEAHLIILDM
1450
QENIIQASSA
1460
LDCKDSLLGG
1470
VLRVLVNSLN
1480
CDQSTTYLTH
1490
CFATLRALIA
1500
KFGDLLFEEE
1510
VEQCFDLCHQ
1520
VLHHCSSSMD
1530
VTRSQACATL
1540
YLLMRFSFGA
1550
TSNFARVKMQ
1560
VTMSLASLVG
1570
RAPDFNEEHL
1580
RRSLRTILAY
1590
SEEDTAMQMT
1600
PFPTQVEELL
1610
CNLNSILYDT
1620
VKMREFQEDP
1630
EMLMDLMYRI
1640
AKSYQASPDL
1650
RLTWLQNMAE
1660
KHTKKKCYTE
1670
AAMCLVHAAA
1680
LVAEYLSMLE
1690
DHSYLPVGSV
1700
SFQNISSNVL
1710
EESVVSEDTL
1720
SPDEDGVCAG
1730
QYFTESGLVG
1740
LLEQAAELFS
1750
TGGLYETVNE
1760
VYKLVIPILE
1770
AHREFRKLTL
1780
THSKLQRAFD
1790
SIVNKDHKRM
1800
FGTYFRVGFF
1810
GSKFGDLDEQ
1820
EFVYKEPAIT
1830
KLPEISHRLE
1840
AFYGQCFGAE
1850
FVEVIKDSTP
1860
VDKTKLDPNK
1870
AYIQITFVEP
1880
YFDEYEMKDR
1890
VTYFEKNFNL
1900
RRFMYTTPFT
1910
LEGRPRGELH
1920
EQYRRNTVLT
1930
TMHAFPYIKT
1940
RISVIQKEEF
1950
VLTPIEVAIE
1960
DMKKKTLQLA
1970
VAINQEPPDA
1980
KMLQMVLQGS
1990
VGATVNQGPL
2000
EVAQVFLAEI
2010
PADPKLYRHH
2020
NKLRLCFKEF
2030
IMRCGEAVEK
2040
NKRLITADQR
2050
EYQQELKKNY
2060
NKLKENLRPM
2070
IERKIPELYK
2080
PIFRVESQKR
2090
DSFHRSSFRK
CETQLSQGS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031252 |
cell leading edge |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031258 |
lamellipodium membrane |
| Cellular Component |
GO:0031256 |
leading edge membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Biological Process |
GO:1990869 |
cellular response to chemokine |
| Biological Process |
GO:0061485 |
memory T cell proliferation |
| Biological Process |
GO:1903905 |
positive regulation of establishment of T cell polarity |
| Biological Process |
GO:0043547 |
positive regulation of GTPase activity |
| Biological Process |
GO:2000406 |
positive regulation of T cell migration |
| Biological Process |
GO:0035023 |
regulation of Rho protein signal transduction |
| Biological Process |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
| Biological Process |
GO:0007264 |
small GTPase-mediated signal transduction |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.