Search Results

Overview

Uniprot IDQ8NF91
Protein NameNesprin-1
Gene NameSYNE1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3127 KLNMMLSKGELLSTL
4333 FQLEDLIKRKIQVSV
45 NSHLAKRKPPMVVDD
8647 NRLKLLLKEVSRHIK

Function

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette

Protein Sequence

10 MATSRGASRC 20 PRDIANVMQR 30 LQDEQEIVQK 40 RTFTKWINSH 50 LAKRKPPMVV 60 DDLFEDMKDG 70 VKLLALLEVL 80 SGQKLPCEQG 90 RRMKRIHAVA 100 NIGTALKFLE 110 GRKIKLVNIN 120 STDIADGRPS 130 IVLGLMWTII 140 LYFQIEELTS 150 NLPQLQSLSS 160 SASSVDSIVS 170 SETPSPPSKR 180 KVTTKIQGNA 190 KKALLKWVQY 200 TAGKQTGIEV 210 KDFGKSWRSG 220 VAFHSVIHAI 230 RPELVDLETV 240 KGRSNRENLE 250 DAFTIAETEL 260 GIPRLLDPED 270 VDVDKPDEKS 280 IMTYVAQFLK 290 HYPDIHNAST 300 DGQEDDEILP 310 GFPSFANSVQ 320 NFKREDRVIF 330 KEMKVWIEQF 340 ERDLTRAQMV 350 ESNLQDKYQS 360 FKHFRVQYEM 370 KRKQIEHLIQ 380 PLHRDGKLSL 390 DQALVKQSWD 400 RVTSRLFDWH 410 IQLDKSLPAP 420 LGTIGAWLYR 430 AEVALREEIT 440 VQQVHEETAN 450 TIQRKLEQHK 460 DLLQNTDAHK 470 RAFHEIYRTR 480 SVNGIPVPPD 490 QLEDMAERFH 500 FVSSTSELHL 510 MKMEFLELKY 520 RLLSLLVLAE 530 SKLKSWIIKY 540 GRRESVEQLL 550 QNYVSFIENS 560 KFFEQYEVTY 570 QILKQTAEMY 580 VKADGSVEEA 590 ENVMKFMNET 600 TAQWRNLSVE 610 VRSVRSMLEE 620 VISNWDRYGN 630 TVASLQAWLE 640 DAEKMLNQSE 650 NAKKDFFRNL 660 PHWIQQHTAM 670 NDAGNFLIET 680 CDEMVSRDLK 690 QQLLLLNGRW 700 RELFMEVKQY 710 AQADEMDRMK 720 KEYTDCVVTL 730 SAFATEAHKK 740 LSEPLEVSFM 750 NVKLLIQDLE 760 DIEQRVPVMD 770 AQYKIITKTA 780 HLITKESPQE 790 EGKEMFATMS 800 KLKEQLTKVK 810 ECYSPLLYES 820 QQLLIPLEEL 830 EKQMTSFYDS 840 LGKINEIITV 850 LEREAQSSAL 860 FKQKHQELLA 870 CQENCKKTLT 880 LIEKGSQSVQ 890 KFVTLSNVLK 900 HFDQTRLQRQ 910 IADIHVAFQS 920 MVKKTGDWKK 930 HVETNSRLMK 940 KFEESRAELE 950 KVLRIAQEGL 960 EEKGDPEELL 970 RRHTEFFSQL 980 DQRVLNAFLK 990 ACDELTDILP 1000 EQEQQGLQEA 1010 VRKLHKQWKD 1020 LQGEAPYHLL 1030 HLKIDVEKNR 1040 FLASVEECRT 1050 ELDRETKLMP 1060 QEGSEKIIKE 1070 HRVFFSDKGP 1080 HHLCEKRLQL 1090 IEELCVKLPV 1100 RDPVRDTPGT 1110 CHVTLKELRA 1120 AIDSTYRKLM 1130 EDPDKWKDYT 1140 SRFSEFSSWI 1150 STNETQLKGI 1160 KGEAIDTANH 1170 GEVKRAVEEI 1180 RNGVTKRGET 1190 LSWLKSRLKV 1200 LTEVSSENEA 1210 QKQGDELAKL 1220 SSSFKALVTL 1230 LSEVEKMLSN 1240 FGDCVQYKEI 1250 VKNSLEELIS 1260 GSKEVQEQAE 1270 KILDTENLFE 1280 AQQLLLHHQQ 1290 KTKRISAKKR 1300 DVQQQIAQAQ 1310 QGEGGLPDRG 1320 HEELRKLEST 1330 LDGLERSRER 1340 QERRIQVTLR 1350 KWERFETNKE 1360 TVVRYLFQTG 1370 SSHERFLSFS 1380 SLESLSSELE 1390 QTKEFSKRTE 1400 SIAVQAENLV 1410 KEASEIPLGP 1420 QNKQLLQQQA 1430 KSIKEQVKKL 1440 EDTLEEDIKT 1450 MEMVKTKWDH 1460 FGSNFETLSV 1470 WITEKEKELN 1480 ALETSSSAMD 1490 MQISQIKVTI 1500 QEIESKLSSI 1510 VGLEEEAQSF 1520 AQFVTTGESA 1530 RIKAKLTQIR 1540 RYGEELREHA 1550 QCLEGTILGH 1560 LSQQQKFEEN 1570 LRKIQQSVSE 1580 FEDKLAVPIK 1590 ICSSATETYK 1600 VLQEHMDLCQ 1610 ALESLSSAIT 1620 AFSASARKVV 1630 NRDSCVQEAA 1640 ALQQQYEDIL 1650 RRAKERQTAL 1660 ENLLAHWQRL 1670 EKELSSFLTW 1680 LERGEAKASS 1690 PEMDISADRV 1700 KVEGELQLIQ 1710 ALQNEVVSQA 1720 SFYSKLLQLK 1730 ESLFSVASKD 1740 DVKMMKLHLE 1750 QLDERWRDLP 1760 QIINKRINFL 1770 QSVVAEHQQF 1780 DELLLSFSVW 1790 IKLFLSELQT 1800 TSEISIMDHQ 1810 VALTRHKDHA 1820 AEVESKKGEL 1830 QSLQGHLAKL 1840 GSLGRAEDLH 1850 LLQGKAEDCF 1860 QLFEEASQVV 1870 ERRQLALSHL 1880 AEFLQSHASL 1890 SGILRQLRQT 1900 VEATNSMNKN 1910 ESDLIEKDLN 1920 DALQNAKALE 1930 SAAVSLDGIL 1940 SKAQYHLKIG 1950 SSEQRTSCRA 1960 TADQLCGEVE 1970 RIQNLLGTKQ 1980 SEADALAVLK 1990 KAFQDQKEEL 2000 LKSIEDIEER 2010 TDKERLKEPT 2020 RQALQQRLRV 2030 FNQLEDELNS 2040 HEHELCWLKD 2050 KAKQIAQKDV 2060 AFAPEVDREI 2070 NRLEVTWDDT 2080 KRLIHENQGQ 2090 CCGLIDLMRE 2100 YQNLKSAVSK 2110 VLENASSVIV 2120 TRTTIKDQED 2130 LKWAFSKHET 2140 AKNKMNYKQK 2150 DLDNFTSKGK 2160 HLLSELKKIH 2170 SSDFSLVKTD 2180 MESTVDKWLD 2190 VSEKLEENMD 2200 RLRVSLSIWD 2210 DVLSTRDEIE 2220 GWSNNCVPQM 2230 AENISNLDNH 2240 LRAEELLKEF 2250 ESEVKNKALR 2260 LEELHSKVND 2270 LKELTKNLET 2280 PPDLQFIEAD 2290 LMQKLEHAKE 2300 ITEVAKGTLK 2310 DFTAQSTQVE 2320 KFINDITTWF 2330 TKVEESLMNC 2340 AQNETCEALK 2350 KVKDIQKELQ 2360 SQQSNISSTQ 2370 ENLNSLCRKY 2380 HSAELESLGR 2390 AMTGLIKKHE 2400 AVSQLCSKTQ 2410 ASLQESLEKH 2420 FSESMQEFQE 2430 WFLGAKAAAK 2440 ESSDRTGDSK 2450 VLEAKLHDLQ 2460 NILDSVSDGQ 2470 SKLDAVTQEG 2480 QTLYAHLSKQ 2490 IVSSIQEQIT 2500 KANEEFQAFL 2510 KQCLKDKQAL 2520 QDCASELGSF 2530 EDQHRKLNLW 2540 IHEMEERFNT 2550 ENLGESKQHI 2560 PEKKNEVHKV 2570 EMFLGELLAA 2580 RESLDKLSQR 2590 GQLLSEEGHG 2600 AGQEGRLCSQ 2610 LLTSHQNLLR 2620 MTKEKLRSCQ 2630 VALQEHEALE 2640 EALQSMWFWV 2650 KAIQDRLACA 2660 ESTLGSKDTL 2670 EKRLSQIQDI 2680 LLMKGEGEVK 2690 LNMAIGKGEQ 2700 ALRSSNKEGQ 2710 RVIQTQLETL 2720 KEVWADIMSS 2730 SVHAQSTLES 2740 VISQWNDYVE 2750 RKNQLEQWME 2760 SVDQKIEHPL 2770 QPQPGLKEKF 2780 VLLDHLQSIL 2790 SEAEDHTRAL 2800 HRLIAKSREL 2810 YEKTEDESFK 2820 DTAQEELKTQ 2830 FNDIMTVAKE 2840 KMRKVEEIVK 2850 DHLMYLDAVH 2860 EFTDWLHSAK 2870 EELHRWSDMS 2880 GDSSATQKKL 2890 SKIKELIDSR 2900 EIGASRLSRV 2910 ESLAPEVKQN 2920 TTASGCELMH 2930 TEMQALRADW 2940 KQWEDSVFQT 2950 QSCLENLVSQ 2960 MALSEQEFSG 2970 QVAQLEQALE 2980 QFSALLKTWA 2990 QQLTLLEGKN 3000 TDEEIVECWH 3010 KGQEILDALQ 3020 KAEPRTEDLK 3030 SQLNELCRFS 3040 RDLSTYSGKV 3050 SGLIKEYNCL 3060 CLQASKGCQN 3070 KEQILQQRFR 3080 KAFRDFQQWL 3090 VNAKITTAKC 3100 FDIPQNISEV 3110 STSLQKIQEF 3120 LSESENGQHK 3130 LNMMLSKGEL 3140 LSTLLTKEKA 3150 KGIQAKVTAA 3160 KEDWKNFHSN 3170 LHQKESALEN 3180 LKIQMKDFEV 3190 SAEPIQDWLS 3200 KTEKMVHESS 3210 NRLYDLPAKR 3220 REQQKLQSVL 3230 EEIHCYEPQL 3240 NRLKEKAQQL 3250 WEGQAASKSF 3260 RHRVSQLSSQ 3270 YLALSNLTKE 3280 KVSRLDRIVA 3290 EHNQFSLGIK 3300 ELQDWMTDAI 3310 HMLDSYCHPT 3320 SDKSVLDSRT 3330 LKLEALLSVK 3340 QEKEIQMKMI 3350 VTRGESVLQN 3360 TSPEGIPTIQ 3370 QQLQSVKDMW 3380 ASLLSAGIRC 3390 KSQLEGALSK 3400 WTSYQDGVRQ 3410 FSGWMDSMEA 3420 NLNESERQHA 3430 ELRDKTTMLG 3440 KAKLLNEEVL 3450 SYSSLLETIE 3460 VKGAGMTEHY 3470 VTQLELQDLQ 3480 ERYRAIQERA 3490 KEAVTKSEKL 3500 VRLHQEYQRD 3510 LKAFEVWLGQ 3520 EQEKLDQYSV 3530 LEGDAHTHET 3540 TLRDLQELQV 3550 HCAEGQALLN 3560 SVLHTREDVI 3570 PSGIPQAEDR 3580 ALESLRQDWQ 3590 AYQHRLSETR 3600 TQFNNVVNKL 3610 RLMEQKFQQV 3620 DEWLKTAEEK 3630 VSPRTRRQSN 3640 RATKEIQLHQ 3650 MKKWHEEVTA 3660 YRDEVEEVGA 3670 RAQEILDESH 3680 VNSRMGCQAT 3690 QLTSRYQALL 3700 LQVLEQIKFL 3710 EEEIQSLEES 3720 ESSLSSYSDW 3730 YGSTHKNFKN 3740 VATKIDKVDT 3750 VMMGKKLKTL 3760 EVLLKDMEKG 3770 HSLLKSAREK 3780 GERAVKYLEE 3790 GEAERLRKEI 3800 HDHMEQLKEL 3810 TSTVRKEHMT 3820 LEKGLHLAKE 3830 FSDKCKALTQ 3840 WIAEYQEILH 3850 VPEEPKMELY 3860 EKKAQLSKYK 3870 SLQQTVLSHE 3880 PSVKSVREKG 3890 EALLELVQDV 3900 TLKDKIDQLQ 3910 SDYQDLCSIG 3920 KEHVFSLEAK 3930 VKDHEDYNSE 3940 LQEVEKWLLQ 3950 MSGRLVAPDL 3960 LETSSLETIT 3970 QQLAHHKAMM 3980 EEIAGFEDRL 3990 NNLQMKGDTL 4000 IGQCADHLQA 4010 KLKQNVHAHL 4020 QGTKDSYSAI 4030 CSTAQRMYQS 4040 LEHELQKHVS 4050 RQDTLQQCQA 4060 WLSAVQPDLE 4070 PSPQPPLSRA 4080 EAIKQVKHFR 4090 ALQEQARTYL 4100 DLLCSMCDLS 4110 NASVKTTAKD 4120 IQQTEQTIEQ 4130 KLVQAQNLTQ 4140 GWEEIKHLKS 4150 ELWIYLQDAD 4160 QQLQNMKRRH 4170 SELELNIAQN 4180 MVSQVKDFVK 4190 KLQSKQASVN 4200 TIIEKVNKLT 4210 KKEESPEHKE 4220 INHLNDQWLD 4230 LCRQSNNLCL 4240 QREEDLQRTR 4250 DYHDCMNVVE 4260 VFLEKFTTEW 4270 DNLARSDAES 4280 TAVHLEALKK 4290 LALALQERKY 4300 AIEDLKDQKQ 4310 KMIEHLNLDD 4320 KELVKEQTSH 4330 LEQRWFQLED 4340 LIKRKIQVSV 4350 TNLEELNVVQ 4360 SRFQELMEWA 4370 EEQQPNIAEA 4380 LKQSPPPDMA 4390 QNLLMDHLAI 4400 CSELEAKQML 4410 LKSLIKDADR 4420 VMADLGLNER 4430 QVIQKALSDA 4440 QSHVNCLSDL 4450 VGQRRKYLNK 4460 ALSEKTQFLM 4470 AVFQATSQIQ 4480 QHERKIMFRE 4490 HICLLPDDVS 4500 KQVKTCKSAQ 4510 ASLKTYQNEV 4520 TGLWAQGREL 4530 MKEVTEQEKS 4540 EVLGKLQELQ 4550 SVYDSVLQKC 4560 SHRLQELEKN 4570 LVSRKHFKED 4580 FDKACHWLKQ 4590 ADIVTFPEIN 4600 LMNESSELHT 4610 QLAKYQNILE 4620 QSPEYENLLL 4630 TLQRTGQTIL 4640 PSLNEVDHSY 4650 LSEKLNALPR 4660 QFNVIVALAK 4670 DKFYKVQEAI 4680 LARKEYASLI 4690 ELTTQSLSEL 4700 EAQFLRMSKV 4710 PTDLAVEEAL 4720 SLQDGCRAIL 4730 DEVAGLGEAV 4740 DELNQKKEGF 4750 RSTGQPWQPD 4760 KMLHLVTLYH 4770 RLKRQTEQRV 4780 SLLEDTTSAY 4790 QEHEKMCQQL 4800 ERQLKSVKEE 4810 QSKVNEETLP 4820 AEEKLKMYHS 4830 LAGSLQDSGI 4840 VLKRVTIHLE 4850 DLAPHLDPLA 4860 YEKARHQIQS 4870 WQGELKLLTS 4880 AIGETVTECE 4890 SRMVQSIDFQ 4900 TEMSRSLDWL 4910 RRVKAELSGP 4920 VYLDLNLQDI 4930 QEEIRKIQIH 4940 QEEVQSSLRI 4950 MNALSHKEKE 4960 KFTKAKELIS 4970 ADLEHSLAEL 4980 SELDGDIQEA 4990 LRTRQATLTE 5000 IYSQCQRYYQ 5010 VFQAANDWLE 5020 DAQELLQLAG 5030 NGLDVESAEE 5040 NLKSHMEFFS 5050 TEDQFHSNLE 5060 ELHSLVATLD 5070 PLIKPTGKED 5080 LEQKVASLEL 5090 RSQRMSRDSG 5100 AQVDLLQRCT 5110 AQWHDYQKAR 5120 EEVIELMNDT 5130 EKKLSEFSLL 5140 KTSSSHEAEE 5150 KLSEHKALVS 5160 VVNSFHEKIV 5170 ALEEKASQLE 5180 KTGNDASKAT 5190 LSRSMTTVWQ 5200 RWTRLRAVAQ 5210 DQEKILEDAV 5220 DEWTGFNNKV 5230 KKATEMIDQL 5240 QDKLPGSSAE 5250 KASKAELLTL 5260 LEYHDTFVLE 5270 LEQQQSALGM 5280 LRQQTLSMLQ 5290 DGAAPTPGEE 5300 PPLMQEITAM 5310 QDRCLNMQEK 5320 VKTNGKLVKQ 5330 ELKDREMVET 5340 QINSVKCWVQ 5350 ETKEYLGNPT 5360 IEIDAQLEEL 5370 QILLTEATNH 5380 RQNIEKMAEE 5390 QKEKYLGLYT 5400 ILPSELSLQL 5410 AEVALDLKIR 5420 DQIQDKIKEV 5430 EQSKATSQEL 5440 SRQIQKLAKD 5450 LTTILTKLKA 5460 KTDNVVQAKT 5470 DQKVLGEELD 5480 GCNSKLMELD 5490 AAVQKFLEQN 5500 GQLGKPLAKK 5510 IGKLTELHQQ 5520 TIRQAENRLS 5530 KLNQAASHLE 5540 EYNEMLELIL 5550 KWIEKAKVLA 5560 HGTIAWNSAS 5570 QLREQYILHQ 5580 TLLEESKEID 5590 SELEAMTEKL 5600 QYLTSVYCTE 5610 KMSQQVAELG 5620 RETEELRQMI 5630 KIRLQNLQDA 5640 AKDMKKFEAE 5650 LKKLQAALEQ 5660 AQATLTSPEV 5670 GRLSLKEQLS 5680 HRQHLLSEME 5690 SLKPKVQAVQ 5700 LCQSALRIPE 5710 DVVASLPLCH 5720 AALRLQEEAS 5730 RLQHTAIQQC 5740 NIMQEAVVQY 5750 EQYEQEMKHL 5760 QQLIEGAHRE 5770 IEDKPVATSN 5780 IQELQAQISR 5790 HEELAQKIKG 5800 YQEQIASLNS 5810 KCKMLTMKAK 5820 HATMLLTVTE 5830 VEGLAEGTED 5840 LDGELLPTPS 5850 AHPSVVMMTA 5860 GRCHTLLSPV 5870 TEESGEEGTN 5880 SEISSPPACR 5890 SPSPVANTDA 5900 SVNQDIAYYQ 5910 ALSAERLQTD 5920 AAKIHPSTSA 5930 SQEFYEPGLE 5940 PSATAKLGDL 5950 QRSWETLKNV 5960 ISEKQRTLYE 5970 ALERQQKYQD 5980 SLQSISTKME 5990 AIELKLSESP 6000 EPGRSPESQM 6010 AEHQALMDEI 6020 LMLQDEINEL 6030 QSSLAEELVS 6040 ESCEADPAEQ 6050 LALQSTLTVL 6060 AERMSTIRMK 6070 ASGKRQLLEE 6080 KLNDQLEEQR 6090 QEQALQRYRC 6100 EADELDSWLL 6110 STKATLDTAL 6120 SPPKEPMDME 6130 AQLMDCQNML 6140 VEIEQKVVAL 6150 SELSVHNENL 6160 LLEGKAHTKD 6170 EAEQLAGKLR 6180 RLKGSLLELQ 6190 RALHDKQLNM 6200 QGTAQEKEES 6210 DVDLTATQSP 6220 GVQEWLAQAR 6230 TTWTQQRQSS 6240 LQQQKELEQE 6250 LAEQKSLLRS 6260 VASRGEEILI 6270 QHSAAETSGD 6280 AGEKPDVLSQ 6290 ELGMEGEKSS 6300 AEDQMRMKWE 6310 SLHQEFSTKQ 6320 KLLQNVLEQE 6330 QEQVLYSRPN 6340 RLLSGVPLYK 6350 GDVPTQDKSA 6360 VTSLLDGLNQ 6370 AFEEVSSQSG 6380 GAKRQSIHLE 6390 QKLYDGVSAT 6400 STWLDDVEER 6410 LFVATALLPE 6420 ETETCLFNQE 6430 ILAKDIKEMS 6440 EEMDKNKNLF 6450 SQAFPENGDN 6460 RDVIEDTLGC 6470 LLGRLSLLDS 6480 VVNQRCHQMK 6490 ERLQQILNFQ 6500 NDLKVLFTSL 6510 ADNKYIILQK 6520 LANVFEQPVA 6530 EQIEAIQQAE 6540 DGLKEFDAGI 6550 IELKRRGDKL 6560 QVEQPSMQEL 6570 SKLQDMYDEL 6580 MMIIGSRRSG 6590 LNQNLTLKSQ 6600 YERALQDLAD 6610 LLETGQEKMA 6620 GDQKIIVSSK 6630 EEIQQLLDKH 6640 KEYFQGLESH 6650 MILTETLFRK 6660 IISFAVQKET 6670 QFHTELMAQA 6680 SAVLKRAHKR 6690 GVELEYILET 6700 WSHLDEDQQE 6710 LSRQLEVVES 6720 SIPSVGLVEE 6730 NEDRLIDRIT 6740 LYQHLKSSLN 6750 EYQPKLYQVL 6760 DDGKRLLISI 6770 SCSDLESQLN 6780 QLGECWLSNT 6790 NKMSKELHRL 6800 ETILKHWTRY 6810 QSESADLIHW 6820 LQSAKDRLEF 6830 WTQQSVTVPQ 6840 ELEMVRDHLN 6850 AFLEFSKEVD 6860 AQSSLKSSVL 6870 STGNQLLRLK 6880 KVDTATLRSE 6890 LSRIDSQWTD 6900 LLTNIPAVQE 6910 KLHQLQMDKL 6920 PSRHAISEVM 6930 SWISLMENVI 6940 QKDEDNIKNS 6950 IGYKAIHEYL 6960 QKYKGFKIDI 6970 NCKQLTVDFV 6980 NQSVLQISSQ 6990 DVESKRSDKT 7000 DFAEQLGAMN 7010 KSWQILQGLV 7020 TEKIQLLEGL 7030 LESWSEYENN 7040 VQCLKTWFET 7050 QEKRLKQQHR 7060 IGDQASVQNA 7070 LKDCQDLEDL 7080 IKAKEKEVEK 7090 IEQNGLALIQ 7100 NKKEDVSSIV 7110 MSTLRELGQT 7120 WANLDHMVGQ 7130 LKILLKSVLD 7140 QWSSHKVAFD 7150 KINSYLMEAR 7160 YSLSRFRLLT 7170 GSLEAVQVQV 7180 DNLQNLQDDL 7190 EKQERSLQKF 7200 GSITNQLLKE 7210 CHPPVTETLT 7220 NTLKEVNMRW 7230 NNLLEEIAEQ 7240 LQSSKALLQL 7250 WQRYKDYSKQ 7260 CASTVQQQED 7270 RTNELLKAAT 7280 NKDIADDEVA 7290 TWIQDCNDLL 7300 KGLGTVKDSL 7310 FFLHELGEQL 7320 KQQVDASAAS 7330 AIQSDQLSLS 7340 QHLCALEQAL 7350 CKQQTSLQAG 7360 VLDYETFAKS 7370 LEALEAWIVE 7380 AEEILQGQDP 7390 SHSSDLSTIQ 7400 ERMEELKGQM 7410 LKFSSMAPDL 7420 DRLNELGYRL 7430 PLNDKEIKRM 7440 QNLNRHWSLI 7450 SSQTTERFSK 7460 LQSFLLQHQT 7470 FLEKCETWME 7480 FLVQTEQKLA 7490 VEISGNYQHL 7500 LEQQRAHELF 7510 QAEMFSRQQI 7520 LHSIIIDGQR 7530 LLEQGQVDDR 7540 DEFNLKLTLL 7550 SNQWQGVIRR 7560 AQQRRGIIDS 7570 QIRQWQRYRE 7580 MAEKLRKWLV 7590 EVSYLPMSGL 7600 GSVPIPLQQA 7610 RTLFDEVQFK 7620 EKVFLRQQGS 7630 YILTVEAGKQ 7640 LLLSADSGAE 7650 AALQAELAEI 7660 QEKWKSASMR 7670 LEEQKKKLAF 7680 LLKDWEKCEK 7690 GIADSLEKLR 7700 TFKKKLSQSL 7710 PDHHEELHAE 7720 QMRCKELENA 7730 VGSWTDDLTQ 7740 LSLLKDTLSA 7750 YISADDISIL 7760 NERVELLQRQ 7770 WEELCHQLSL 7780 RRQQIGERLN 7790 EWAVFSEKNK 7800 ELCEWLTQME 7810 SKVSQNGDIL 7820 IEEMIEKLKK 7830 DYQEEIAIAQ 7840 ENKIQLQQMG 7850 ERLAKASHES 7860 KASEIEYKLG 7870 KVNDRWQHLL 7880 DLIAARVKKL 7890 KETLVAVQQL 7900 DKNMSSLRTW 7910 LAHIESELAK 7920 PIVYDSCNSE 7930 EIQRKLNEQQ 7940 ELQRDIEKHS 7950 TGVASVLNLC 7960 EVLLHDCDAC 7970 ATDAECDSIQ 7980 QATRNLDRRW 7990 RNICAMSMER 8000 RLKIEETWRL 8010 WQKFLDDYSR 8020 FEDWLKSSER 8030 TAAFPSSSGV 8040 IYTVAKEELK 8050 KFEAFQRQVH 8060 ECLTQLELIN 8070 KQYRRLAREN 8080 RTDSACSLKQ 8090 MVHEGNQRWD 8100 NLQKRVTSIL 8110 RRLKHFIGQR 8120 EEFETARDSI 8130 LVWLTEMDLQ 8140 LTNIEHFSEC 8150 DVQAKIKQLK 8160 AFQQEISLNH 8170 NKIEQIIAQG 8180 EQLIEKSEPL 8190 DAAIIEEELD 8200 ELRRYCQEVF 8210 GRVERYHKKL 8220 IRLPLPDDEH 8230 DLSDRELELE 8240 DSAALSDLHW 8250 HDRSADSLLS 8260 PQPSSNLSLS 8270 LAQPLRSERS 8280 GRDTPASVDS 8290 IPLEWDHDYD 8300 LSRDLESAMS 8310 RALPSEDEEG 8320 QDDKDFYLRG 8330 AVGLSGDHSA 8340 LESQIRQLGK 8350 ALDDSRFQIQ 8360 QTENIIRSKT 8370 PTGPELDTSY 8380 KGYMKLLGEC 8390 SSSIDSVKRL 8400 EHKLKEEEES 8410 LPGFVNLHST 8420 ETQTAGVIDR 8430 WELLQAQALS 8440 KELRMKQNLQ 8450 KWQQFNSDLN 8460 SIWAWLGDTE 8470 EELEQLQRLE 8480 LSTDIQTIEL 8490 QIKKLKELQK 8500 AVDHRKAIIL 8510 SINLCSPEFT 8520 QADSKESRDL 8530 QDRLSQMNGR 8540 WDRVCSLLEE 8550 WRGLLQDALM 8560 QCQGFHEMSH 8570 GLLLMLENID 8580 RRKNEIVPID 8590 SNLDAEILQD 8600 HHKQLMQIKH 8610 ELLESQLRVA 8620 SLQDMSCQLL 8630 VNAEGTDCLE 8640 AKEKVHVIGN 8650 RLKLLLKEVS 8660 RHIKELEKLL 8670 DVSSSQQDLS 8680 SWSSADELDT 8690 SGSVSPTSGR 8700 STPNRQKTPR 8710 GKCSLSQPGP 8720 SVSSPHSRST 8730 KGGSDSSLSE 8740 PGPGRSGRGF 8750 LFRVLRAALP 8760 LQLLLLLLIG 8770 LACLVPMSEE 8780 DYSCALSNNF 8790 ARSFHPMLRY TNGPPPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0034993 meiotic nuclear membrane microtubule tethering complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005640 nuclear outer membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0016529 sarcoplasmic reticulum
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0140444 cytoskeleton-nuclear membrane anchor activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005521 lamin binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0051642 centrosome localization
Biological Process GO:0007030 Golgi organization
Biological Process GO:0042692 muscle cell differentiation
Biological Process GO:0090292 nuclear matrix anchoring at nuclear membrane
Biological Process GO:0007097 nuclear migration
Biological Process GO:0006997 nucleus organization
Biological Process GO:1902017 regulation of cilium assembly
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.