Search Results

Overview

Uniprot IDQ8NFA0
Protein NameUbiquitin carboxyl-terminal hydrolase 32
Gene NameUSP32
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
26 RVTDVELKRLKDAFK

Function

Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874)

Protein Sequence

10 MGAKESRIGF 20 LSYEEALRRV 30 TDVELKRLKD 40 AFKRTCGLSY 50 YMGQHCFIRE 60 VLGDGVPPKV 70 AEVIYCSFGG 80 TSKGLHFNNL 90 IVGLVLLTRG 100 KDEEKAKYIF 110 SLFSSESGNY 120 VIREEMERML 130 HVVDGKVPDT 140 LRKCFSEGEK 150 VNYEKFRNWL 160 FLNKDAFTFS 170 RWLLSGGVYV 180 TLTDDSDTPT 190 FYQTLAGVTH 200 LEESDIIDLE 210 KRYWLLKAQS 220 RTGRFDLETF 230 GPLVSPPIRP 240 SLSEGLFNAF 250 DENRDNHIDF 260 KEISCGLSAC 270 CRGPLAERQK 280 FCFKVFDVDR 290 DGVLSRVELR 300 DMVVALLEVW 310 KDNRTDDIPE 320 LHMDLSDIVE 330 GILNAHDTTK 340 MGHLTLEDYQ 350 IWSVKNVLAN 360 EFLNLLFQVC 370 HIVLGLRPAT 380 PEEEGQIIRG 390 WLERESRYGL 400 QAGHNWFIIS 410 MQWWQQWKEY 420 VKYDANPVVI 430 EPSSVLNGGK 440 YSFGTAAHPM 450 EQVEDRIGSS 460 LSYVNTTEEK 470 FSDNISTASE 480 ASETAGSGFL 490 YSATPGADVC 500 FARQHNTSDN 510 NNQCLLGANG 520 NILLHLNPQK 530 PGAIDNQPLV 540 TQEPVKATSL 550 TLEGGRLKRT 560 PQLIHGRDYE 570 MVPEPVWRAL 580 YHWYGANLAL 590 PRPVIKNSKT 600 DIPELELFPR 610 YLLFLRQQPA 620 TRTQQSNIWV 630 NMGNVPSPNA 640 PLKRVLAYTG 650 CFSRMQTIKE 660 IHEYLSQRLR 670 IKEEDMRLWL 680 YNSENYLTLL 690 DDEDHKLEYL 700 KIQDEQHLVI 710 EVRNKDMSWP 720 EEMSFIANSS 730 KIDRHKVPTE 740 KGATGLSNLG 750 NTCFMNSSIQ 760 CVSNTQPLTQ 770 YFISGRHLYE 780 LNRTNPIGMK 790 GHMAKCYGDL 800 VQELWSGTQK 810 NVAPLKLRWT 820 IAKYAPRFNG 830 FQQQDSQELL 840 AFLLDGLHED 850 LNRVHEKPYV 860 ELKDSDGRPD 870 WEVAAEAWDN 880 HLRRNRSIVV 890 DLFHGQLRSQ 900 VKCKTCGHIS 910 VRFDPFNFLS 920 LPLPMDSYMH 930 LEITVIKLDG 940 TTPVRYGLRL 950 NMDEKYTGLK 960 KQLSDLCGLN 970 SEQILLAEVH 980 GSNIKNFPQD 990 NQKVRLSVSG 1000 FLCAFEIPVP 1010 VSPISASSPT 1020 QTDFSSSPST 1030 NEMFTLTTNG 1040 DLPRPIFIPN 1050 GMPNTVVPCG 1060 TEKNFTNGMV 1070 NGHMPSLPDS 1080 PFTGYIIAVH 1090 RKMMRTELYF 1100 LSSQKNRPSL 1110 FGMPLIVPCT 1120 VHTRKKDLYD 1130 AVWIQVSRLA 1140 SPLPPQEASN 1150 HAQDCDDSMG 1160 YQYPFTLRVV 1170 QKDGNSCAWC 1180 PWYRFCRGCK 1190 IDCGEDRAFI 1200 GNAYIAVDWD 1210 PTALHLRYQT 1220 SQERVVDEHE 1230 SVEQSRRAQA 1240 EPINLDSCLR 1250 AFTSEEELGE 1260 NEMYYCSKCK 1270 THCLATKKLD 1280 LWRLPPILII 1290 HLKRFQFVNG 1300 RWIKSQKIVK 1310 FPRESFDPSA 1320 FLVPRDPALC 1330 QHKPLTPQGD 1340 ELSEPRILAR 1350 EVKKVDAQSS 1360 AGEEDVLLSK 1370 SPSSLSANII 1380 SSPKGSPSSS 1390 RKSGTSCPSS 1400 KNSSPNSSPR 1410 TLGRSKGRLR 1420 LPQIGSKNKL 1430 SSSKENLDAS 1440 KENGAGQICE 1450 LADALSRGHV 1460 LGGSQPELVT 1470 PQDHEVALAN 1480 GFLYEHEACG 1490 NGYSNGQLGN 1500 HSEEDSTDDQ 1510 REDTRIKPIY 1520 NLYAISCHSG 1530 ILGGGHYVTY 1540 AKNPNCKWYC 1550 YNDSSCKELH 1560 PDEIDTDSAY 1570 ILFYEQQGID 1580 YAQFLPKTDG 1590 KKMADTSSMD 1600 EDFESDYKKY CVLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Biological Process GO:1904263 positive regulation of TORC1 signaling
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006508 proteolysis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.