Search Results
Overview
| Uniprot ID | Q8NFA0 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 32 |
| Gene Name | USP32 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | RVTDVELKRLKDAFK |
Function
Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874)
Protein Sequence
10
MGAKESRIGF
20
LSYEEALRRV
30
TDVELKRLKD
40
AFKRTCGLSY
50
YMGQHCFIRE
60
VLGDGVPPKV
70
AEVIYCSFGG
80
TSKGLHFNNL
90
IVGLVLLTRG
100
KDEEKAKYIF
110
SLFSSESGNY
120
VIREEMERML
130
HVVDGKVPDT
140
LRKCFSEGEK
150
VNYEKFRNWL
160
FLNKDAFTFS
170
RWLLSGGVYV
180
TLTDDSDTPT
190
FYQTLAGVTH
200
LEESDIIDLE
210
KRYWLLKAQS
220
RTGRFDLETF
230
GPLVSPPIRP
240
SLSEGLFNAF
250
DENRDNHIDF
260
KEISCGLSAC
270
CRGPLAERQK
280
FCFKVFDVDR
290
DGVLSRVELR
300
DMVVALLEVW
310
KDNRTDDIPE
320
LHMDLSDIVE
330
GILNAHDTTK
340
MGHLTLEDYQ
350
IWSVKNVLAN
360
EFLNLLFQVC
370
HIVLGLRPAT
380
PEEEGQIIRG
390
WLERESRYGL
400
QAGHNWFIIS
410
MQWWQQWKEY
420
VKYDANPVVI
430
EPSSVLNGGK
440
YSFGTAAHPM
450
EQVEDRIGSS
460
LSYVNTTEEK
470
FSDNISTASE
480
ASETAGSGFL
490
YSATPGADVC
500
FARQHNTSDN
510
NNQCLLGANG
520
NILLHLNPQK
530
PGAIDNQPLV
540
TQEPVKATSL
550
TLEGGRLKRT
560
PQLIHGRDYE
570
MVPEPVWRAL
580
YHWYGANLAL
590
PRPVIKNSKT
600
DIPELELFPR
610
YLLFLRQQPA
620
TRTQQSNIWV
630
NMGNVPSPNA
640
PLKRVLAYTG
650
CFSRMQTIKE
660
IHEYLSQRLR
670
IKEEDMRLWL
680
YNSENYLTLL
690
DDEDHKLEYL
700
KIQDEQHLVI
710
EVRNKDMSWP
720
EEMSFIANSS
730
KIDRHKVPTE
740
KGATGLSNLG
750
NTCFMNSSIQ
760
CVSNTQPLTQ
770
YFISGRHLYE
780
LNRTNPIGMK
790
GHMAKCYGDL
800
VQELWSGTQK
810
NVAPLKLRWT
820
IAKYAPRFNG
830
FQQQDSQELL
840
AFLLDGLHED
850
LNRVHEKPYV
860
ELKDSDGRPD
870
WEVAAEAWDN
880
HLRRNRSIVV
890
DLFHGQLRSQ
900
VKCKTCGHIS
910
VRFDPFNFLS
920
LPLPMDSYMH
930
LEITVIKLDG
940
TTPVRYGLRL
950
NMDEKYTGLK
960
KQLSDLCGLN
970
SEQILLAEVH
980
GSNIKNFPQD
990
NQKVRLSVSG
1000
FLCAFEIPVP
1010
VSPISASSPT
1020
QTDFSSSPST
1030
NEMFTLTTNG
1040
DLPRPIFIPN
1050
GMPNTVVPCG
1060
TEKNFTNGMV
1070
NGHMPSLPDS
1080
PFTGYIIAVH
1090
RKMMRTELYF
1100
LSSQKNRPSL
1110
FGMPLIVPCT
1120
VHTRKKDLYD
1130
AVWIQVSRLA
1140
SPLPPQEASN
1150
HAQDCDDSMG
1160
YQYPFTLRVV
1170
QKDGNSCAWC
1180
PWYRFCRGCK
1190
IDCGEDRAFI
1200
GNAYIAVDWD
1210
PTALHLRYQT
1220
SQERVVDEHE
1230
SVEQSRRAQA
1240
EPINLDSCLR
1250
AFTSEEELGE
1260
NEMYYCSKCK
1270
THCLATKKLD
1280
LWRLPPILII
1290
HLKRFQFVNG
1300
RWIKSQKIVK
1310
FPRESFDPSA
1320
FLVPRDPALC
1330
QHKPLTPQGD
1340
ELSEPRILAR
1350
EVKKVDAQSS
1360
AGEEDVLLSK
1370
SPSSLSANII
1380
SSPKGSPSSS
1390
RKSGTSCPSS
1400
KNSSPNSSPR
1410
TLGRSKGRLR
1420
LPQIGSKNKL
1430
SSSKENLDAS
1440
KENGAGQICE
1450
LADALSRGHV
1460
LGGSQPELVT
1470
PQDHEVALAN
1480
GFLYEHEACG
1490
NGYSNGQLGN
1500
HSEEDSTDDQ
1510
REDTRIKPIY
1520
NLYAISCHSG
1530
ILGGGHYVTY
1540
AKNPNCKWYC
1550
YNDSSCKELH
1560
PDEIDTDSAY
1570
ILFYEQQGID
1580
YAQFLPKTDG
1590
KKMADTSSMD
1600
EDFESDYKKY
CVLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Biological Process | GO:1904263 | positive regulation of TORC1 signaling |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.