Search Results

Overview

Uniprot IDQ8NFC6
Protein NameBiorientation of chromosomes in cell division protein 1-like 1
Gene NameBOD1L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1065 NSSLMEKKLSRRLCE
1215 HIQSAVSKMNPGEKE
1257 DRVQKNLKNTAAEEH
2569 NLKTSTTKCITGQES
2774 HMPKRKRKQHYLSSE
2872 EDQPIIIKRKRGRPR
2880 RKRGRPRKYPVETTL
2910 EQSPSSSKLKVMQTD
2912 SPSSSKLKVMQTDES
3015 RSEAQRSKTQLSPSI
3047 RVEEAPVKKAKR***
3048 VEEAPVKKAKR****
692 ICTEEPQKQKSTLKN
694 TEEPQKQKSTLKNEK
738 EKTPSEDKLSVKHKY
780 QKQSQQTKLSSDDKT
849 SRRSSDSKIQKDSLG
852 SSDSKIQKDSLGSKQ
907 TKSLLEEKLVLKSKS
993 KDSSHRAKLPLAKEK

Function

Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705)

Protein Sequence

10 MATNPQPQPP 20 PPAPPPPPPQ 30 PQPQPPPPPP 40 GPGAGPGAGG 50 AGGAGAGAGD 60 PQLVAMIVNH 70 LKSQGLFDQF 80 RRDCLADVDT 90 KPAYQNLRQR 100 VDNFVANHLA 110 THTWSPHLNK 120 NQLRNNIRQQ 130 VLKSGMLESG 140 IDRIISQVVD 150 PKINHTFRPQ 160 VEKAVHEFLA 170 TLNHKEEGSG 180 NTAPDDEKPD 190 TSLITQGVPT 200 PGPSANVAND 210 AMSILETITS 220 LNQEASAARA 230 STETSNAKTS 240 ERASKKLPSQ 250 PTTDTSTDKE 260 RTSEDMADKE 270 KSTADSGGEG 280 LETAPKSEEF 290 SDLPCPVEEI 300 KNYTKEHNNL 310 ILLNKDVQQE 320 SSEQKNKSTD 330 KGEKKPDSNE 340 KGERKKEKKE 350 KTEKKFDHSK 360 KSEDTQKVKD 370 EKQAKEKEVE 380 SLKLPSEKNS 390 NKAKTVEGTK 400 EDFSLIDSDV 410 DGLTDITVSS 420 VHTSDLSSFE 430 EDTEEEVVTS 440 DSMEEGEITS 450 DDEEKNKQNK 460 TKTQTSDSSE 470 GKTKSVRHAY 480 VHKPYLYSKY 490 YSDSDDELTV 500 EQRRQSIAKE 510 KEERLLRRQI 520 NREKLEEKRK 530 QKAEKTKSSK 540 TKGQGRSSVD 550 LEESSTKSLE 560 PKAARIKEVL 570 KERKVLEKKV 580 ALSKKRKKDS 590 RNVEENSKKK 600 QQYEEDSKET 610 LKTSEHCEKE 620 KISSSKELKH 630 VHAKSEPSKP 640 ARRLSESLHV 650 VDENKNESKL 660 EREHKRRTST 670 PVIMEGVQEE 680 TDTRDVKRQV 690 ERSEICTEEP 700 QKQKSTLKNE 710 KHLKKDDSET 720 PHLKSLLKKE 730 VKSSKEKPER 740 EKTPSEDKLS 750 VKHKYKGDCM 760 HKTGDETELH 770 SSEKGLKVEE 780 NIQKQSQQTK 790 LSSDDKTERK 800 SKHRNERKLS 810 VLGKDGKPVS 820 EYIIKTDENV 830 RKENNKKERR 840 LSAEKTKAEH 850 KSRRSSDSKI 860 QKDSLGSKQH 870 GITLQRRSES 880 YSEDKCDMDS 890 TNMDSNLKPE 900 EVVHKEKRRT 910 KSLLEEKLVL 920 KSKSKTQGKQ 930 VKVVETELQE 940 GATKQATTPK 950 PDKEKNTEEN 960 DSEKQRKSKV 970 EDKPFEETGV 980 EPVLETASSS 990 AHSTQKDSSH 1000 RAKLPLAKEK 1010 YKSDKDSTST 1020 RLERKLSDGH 1030 KSRSLKHSSK 1040 DIKKKDENKS 1050 DDKDGKEVDS 1060 SHEKARGNSS 1070 LMEKKLSRRL 1080 CENRRGSLSQ 1090 EMAKGEEKLA 1100 ANTLSTPSGS 1110 SLQRPKKSGD 1120 MTLIPEQEPM 1130 EIDSEPGVEN 1140 VFEVSKTQDN 1150 RNNNSQQDID 1160 SENMKQKTSA 1170 TVQKDELRTC 1180 TADSKATAPA 1190 YKPGRGTGVN 1200 SNSEKHADHR 1210 STLTKKMHIQ 1220 SAVSKMNPGE 1230 KEPIHRGTTE 1240 VNIDSETVHR 1250 MLLSAPSEND 1260 RVQKNLKNTA 1270 AEEHVAQGDA 1280 TLEHSTNLDS 1290 SPSLSSVTVV 1300 PLRESYDPDV 1310 IPLFDKRTVL 1320 EGSTASTSPA 1330 DHSALPNQSL 1340 TVRESEVLKT 1350 SDSKEGGEGF 1360 TVDTPAKASI 1370 TSKRHIPEAH 1380 QATLLDGKQG 1390 KVIMPLGSKL 1400 TGVIVENENI 1410 TKEGGLVDMA 1420 KKENDLNAEP 1430 NLKQTIKATV 1440 ENGKKDGIAV 1450 DHVVGLNTEK 1460 YAETVKLKHK 1470 RSPGKVKDIS 1480 IDVERRNENS 1490 EVDTSAGSGS 1500 APSVLHQRNG 1510 QTEDVATGPR 1520 RAEKTSVATS 1530 TEGKDKDVTL 1540 SPVKAGPATT 1550 TSSETRQSEV 1560 ALPCTSIEAD 1570 EGLIIGTHSR 1580 NNPLHVGAEA 1590 SECTVFAAAE 1600 EGGAVVTEGF 1610 AESETFLTST 1620 KEGESGECAV 1630 AESEDRAADL 1640 LAVHAVKIEA 1650 NVNSVVTEEK 1660 DDAVTSAGSE 1670 EKCDGSLSRD 1680 SEIVEGTITF 1690 ISEVESDGAV 1700 TSAGTEIRAG 1710 SISSEEVDGS 1720 QGNMMRMGPK 1730 KETEGTVTCT 1740 GAEGRSDNFV 1750 ICSVTGAGPR 1760 EERMVTGAGV 1770 VLGDNDAPPG 1780 TSASQEGDGS 1790 VNDGTEGESA 1800 VTSTGITEDG 1810 EGPASCTGSE 1820 DSSEGFAISS 1830 ESEENGESAM 1840 DSTVAKEGTN 1850 VPLVAAGPCD 1860 DEGIVTSTGA 1870 KEEDEEGEDV 1880 VTSTGRGNEI 1890 GHASTCTGLG 1900 EESEGVLICE 1910 SAEGDSQIGT 1920 VVEHVEAEAG 1930 AAIMNANENN 1940 VDSMSGTEKG 1950 SKDTDICSSA 1960 KGIVESSVTS 1970 AVSGKDEVTP 1980 VPGGCEGPMT 1990 SAASDQSDSQ 2000 LEKVEDTTIS 2010 TGLVGGSYDV 2020 LVSGEVPECE 2030 VAHTSPSEKE 2040 DEDIITSVEN 2050 EECDGLMATT 2060 ASGDITNQNS 2070 LAGGKNQGKV 2080 LIISTSTTND 2090 YTPQVSAITD 2100 VEGGLSDALR 2110 TEENMEGTRV 2120 TTEEFEAPMP 2130 SAVSGDDSQL 2140 TASRSEEKDE 2150 CAMISTSIGE 2160 EFELPISSAT 2170 TIKCAESLQP 2180 VAAAVEERAT 2190 GPVLISTADF 2200 EGPMPSAPPE 2210 AESPLASTSK 2220 EEKDECALIS 2230 TSIAEECEAS 2240 VSGVVVESEN 2250 ERAGTVMEEK 2260 DGSGIISTSS 2270 VEDCEGPVSS 2280 AVPQEEGDPS 2290 VTPAEEMGDT 2300 AMISTSTSEG 2310 CEAVMIGAVL 2320 QDEDRLTITR 2330 VEDLSDAAII 2340 STSTAECMPI 2350 SASIDRHEEN 2360 QLTADNPEGN 2370 GDLSATEVSK 2380 HKVPMPSLIA 2390 ENNCRCPGPV 2400 RGGKEPGPVL 2410 AVSTEEGHNG 2420 PSVHKPSAGQ 2430 GHPSAVCAEK 2440 EEKHGKECPE 2450 IGPFAGRGQK 2460 ESTLHLINAE 2470 EKNVLLNSLQ 2480 KEDKSPETGT 2490 AGGSSTASYS 2500 AGRGLEGNAN 2510 SPAHLRGPEQ 2520 TSGQTAKDPS 2530 VSIRYLAAVN 2540 TGAIKADDMP 2550 PVQGTVAEHS 2560 FLPAEQQGSE 2570 DNLKTSTTKC 2580 ITGQESKIAP 2590 SHTMIPPATY 2600 SVALLAPKCE 2610 QDLTIKNDYS 2620 GKWTDQASAE 2630 KTGDDNSTRK 2640 SFPEEGDIMV 2650 TVSSEENVCD 2660 IGNEESPLNV 2670 LGGLKLKANL 2680 KMEAYVPSEE 2690 EKNGEILAPP 2700 ESLCGGKPSG 2710 IAELQREPLL 2720 VNESLNVENS 2730 GFRTNEEIHS 2740 ESYNKGEISS 2750 GRKDNAEAIS 2760 GHSVEADPKE 2770 VEEEERHMPK 2780 RKRKQHYLSS 2790 EDEPDDNPDV 2800 LDSRIETAQR 2810 QCPETEPHDT 2820 KEENSRDLEE 2830 LPKTSSETNS 2840 TTSRVMEEKD 2850 EYSSSETTGE 2860 KPEQNDDDTI 2870 KSQEEDQPII 2880 IKRKRGRPRK 2890 YPVETTLKMK 2900 DDSKTDTGIV 2910 TVEQSPSSSK 2920 LKVMQTDESN 2930 KETANLQERS 2940 ISNDDGEEKI 2950 VTSVRRRGRK 2960 PKRSLTVSDD 2970 AESSEPERKR 2980 QKSVSDPVED 2990 KKEQESDEEE 3000 EEEEEDEPSG 3010 ATTRSTTRSE 3020 AQRSKTQLSP 3030 SIKRKREVSP 3040 PGARTRGQQR 3050 VEEAPVKKAK R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0048188 Set1C/COMPASS complex
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:0031297 replication fork processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.