Search Results

Overview

Uniprot ID	Q8NFD5
Protein Name	AT-rich interactive domain-containing protein 1B
Gene Name	ARID1B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1165	SSLPAVGKKPLDLFR
1166	SLPAVGKKPLDLFRL
1649	SPFLPSMKMQKVMPT

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388)

Protein Sequence

10 MAARAAAAAA 20 AAAARARARA 30 GSGERRAPPG 40 PRPAPGARDL 50 EAGARGAAAA 60 AAAPGPMLGG 70 GGDGGGGLNS 80 VHHHPLLPRH 90 ELNMAHNAGA 100 AAAAGTHSAK 110 SGGSEAALKE 120 GGSAAALSSS 130 SSSSAAAAAA 140 SSSSSSGPGS 150 AMETGLLPNH 160 KLKTVGEAPA 170 APPHQQHHHH 180 HHAHHHHHHA 190 HHLHHHHALQ 200 QQLNQFQQQQ 210 QQQQQQQQQQ 220 QQQQHPISNN 230 NSLGGAGGGA 240 PQPGPDMEQP 250 QHGGAKDSAA 260 GGQADPPGPP 270 LLSKPGDEDD 280 APPKMGEPAG 290 GRYEHPGLGA 300 LGTQQPPVAV 310 PGGGGGPAAV 320 PEFNNYYGSA 330 APASGGPGGR 340 AGPCFDQHGG 350 QQSPGMGMMH 360 SASAAAAGAP 370 GSMDPLQNSH 380 EGYPNSQCNH 390 YPGYSRPGAG 400 GGGGGGGGGG 410 GGSGGGGGGG 420 GAGAGGAGAG 430 AVAAAAAAAA 440 AAAGGGGGGG 450 YGGSSAGYGV 460 LSSPRQQGGG 470 MMMGPGGGGA 480 ASLSKAAAGS 490 AAGGFQRFAG 500 QNQHPSGATP 510 TLNQLLTSPS 520 PMMRSYGGSY 530 PEYSSPSAPP 540 PPPSQPQSQA 550 AAAGAAAGGQ 560 QAAAGMGLGK 570 DMGAQYAAAS 580 PAWAAAQQRS 590 HPAMSPGTPG 600 PTMGRSQGSP 610 MDPMVMKRPQ 620 LYGMGSNPHS 630 QPQQSSPYPG 640 GSYGPPGPQR 650 YPIGIQGRTP 660 GAMAGMQYPQ 670 QQMPPQYGQQ 680 GVSGYCQQGQ 690 QPYYSQQPQP 700 PHLPPQAQYL 710 PSQSQQRYQP 720 QQDMSQEGYG 730 TRSQPPLAPG 740 KPNHEDLNLI 750 QQERPSSLPD 760 LSGSIDDLPT 770 GTEATLSSAV 780 SASGSTSSQG 790 DQSNPAQSPF 800 SPHASPHLSS 810 IPGGPSPSPV 820 GSPVGSNQSR 830 SGPISPASIP 840 GSQMPPQPPG 850 SQSESSSHPA 860 LSQSPMPQER 870 GFMAGTQRNP 880 QMAQYGPQQT 890 GPSMSPHPSP 900 GGQMHAGISS 910 FQQSNSSGTY 920 GPQMSQYGPQ 930 GNYSRPPAYS 940 GVPSASYSGP 950 GPGMGISANN 960 QMHGQGPSQP 970 CGAVPLGRMP 980 SAGMQNRPFP 990 GNMSSMTPSS 1000 PGMSQQGGPG 1010 MGPPMPTVNR 1020 KAQEAAAAVM 1030 QAAANSAQSR 1040 QGSFPGMNQS 1050 GLMASSSPYS 1060 QPMNNSSSLM 1070 NTQAPPYSMA 1080 PAMVNSSAAS 1090 VGLADMMSPG 1100 ESKLPLPLKA 1110 DGKEEGTPQP 1120 ESKSKKSSSS 1130 TTTGEKITKV 1140 YELGNEPERK 1150 LWVDRYLTFM 1160 EERGSPVSSL 1170 PAVGKKPLDL 1180 FRLYVCVKEI 1190 GGLAQVNKNK 1200 KWRELATNLN 1210 VGTSSSAASS 1220 LKKQYIQYLF 1230 AFECKIERGE 1240 EPPPEVFSTG 1250 DTKKQPKLQP 1260 PSPANSGSLQ 1270 GPQTPQSTGS 1280 NSMAEVPGDL 1290 KPPTPASTPH 1300 GQMTPMQGGR 1310 SSTISVHDPF 1320 SDVSDSSFPK 1330 RNSMTPNAPY 1340 QQGMSMPDVM 1350 GRMPYEPNKD 1360 PFGGMRKVPG 1370 SSEPFMTQGQ 1380 MPNSSMQDMY 1390 NQSPSGAMSN 1400 LGMGQRQQFP 1410 YGASYDRRHE 1420 PYGQQYPGQG 1430 PPSGQPPYGG 1440 HQPGLYPQQP 1450 NYKRHMDGMY 1460 GPPAKRHEGD 1470 MYNMQYSSQQ 1480 QEMYNQYGGS 1490 YSGPDRRPIQ 1500 GQYPYPYSRE 1510 RMQGPGQIQT 1520 HGIPPQMMGG 1530 PLQSSSSEGP 1540 QQNMWAARND 1550 MPYPYQNRQG 1560 PGGPTQAPPY 1570 PGMNRTDDMM 1580 VPDQRINHES 1590 QWPSHVSQRQ 1600 PYMSSSASMQ 1610 PITRPPQPSY 1620 QTPPSLPNHI 1630 SRAPSPASFQ 1640 RSLENRMSPS 1650 KSPFLPSMKM 1660 QKVMPTVPTS 1670 QVTGPPPQPP 1680 PIRREITFPP 1690 GSVEASQPVL 1700 KQRRKITSKD 1710 IVTPEAWRVM 1720 MSLKSGLLAE 1730 STWALDTINI 1740 LLYDDSTVAT 1750 FNLSQLSGFL 1760 ELLVEYFRKC 1770 LIDIFGILME 1780 YEVGDPSQKA 1790 LDHNAARKDD 1800 SQSLADDSGK 1810 EEEDAECIDD 1820 DEEDEEDEEE 1830 DSEKTESDEK 1840 SSIALTAPDA 1850 AADPKEKPKQ 1860 ASKFDKLPIK 1870 IVKKNNLFVV 1880 DRSDKLGRVQ 1890 EFNSGLLHWQ 1900 LGGGDTTEHI 1910 QTHFESKMEI 1920 PPRRRPPPPL 1930 SSAGRKKEQE 1940 GKGDSEEQQE 1950 KSIIATIDDV 1960 LSARPGALPE 1970 DANPGPQTES 1980 SKFPFGIQQA 1990 KSHRNIKLLE 2000 DEPRSRDETP 2010 LCTIAHWQDS 2020 LAKRCICVSN 2030 IVRSLSFVPG 2040 NDAEMSKHPG 2050 LVLILGKLIL 2060 LHHEHPERKR 2070 APQTYEKEED 2080 EDKGVACSKD 2090 EWWWDCLEVL 2100 RDNTLVTLAN 2110 ISGQLDLSAY 2120 TESICLPILD 2130 GLLHWMVCPS 2140 AEAQDPFPTV 2150 GPNSVLSPQR 2160 LVLETLCKLS 2170 IQDNNVDLIL 2180 ATPPFSRQEK 2190 FYATLVRYVG 2200 DRKNPVCREM 2210 SMALLSNLAQ 2220 GDALAARAIA 2230 VQKGSIGNLI 2240 SFLEDGVTMA 2250 QYQQSQHNLM 2260 HMQPPPLEPP 2270 SVDMMCRAAK 2280 ALLAMARVDE 2290 NRSEFLLHEG 2300 RLLDISISAV 2310 LNSLVASVIC DVLFQIGQL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035060	brahma complex
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0071565	nBAF complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0016514	SWI/SNF complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0045597	positive regulation of cell differentiation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:2000781	positive regulation of double-strand break repair
Biological Process	GO:0045663	positive regulation of myoblast differentiation
Biological Process	GO:0045582	positive regulation of T cell differentiation
Biological Process	GO:0070316	regulation of G0 to G1 transition
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition
Biological Process	GO:2000819	regulation of nucleotide-excision repair
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.