Search Results

Overview

Uniprot ID	Q8NFH8
Protein Name	RalBP1-associated Eps domain-containing protein 2
Gene Name	REPS2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
214	PLSHGYSKLRSSAEQ
508	QPSVPATKSGLLPPP

Function

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250)

Protein Sequence

10 MEAAAAAAAA 20 AAAAAAAGGG 30 CGSGPPPLLL 40 SEGEQQCYSE 50 LFARCAGAAG 60 GGPGSGPPEA 70 ARVAPGTATA 80 AAGPVADLFR 90 ASQLPAETLH 100 QITELCGAKR 110 VGYFGPTQFY 120 IALKLIAAAQ 130 SGLPVRIESI 140 KCELPLPRFM 150 MSKNDGEIRF 160 GNPAELHGTK 170 VQIPYLTTEK 180 NSFKRMDDED 190 KQQETQSPTM 200 SPLASPPSSP 210 PHYQRVPLSH 220 GYSKLRSSAE 230 QMHPAPYEAR 240 QPLVQPEGSS 250 SGGPGTKPLR 260 HQASLIRSFS 270 VERELQDNSS 280 YPDEPWRITE 290 EQREYYVNQF 300 RSLQPDPSSF 310 ISGSVAKNFF 320 TKSKLSIPEL 330 SYIWELSDAD 340 CDGALTLPEF 350 CAAFHLIVAR 360 KNGYPLPEGL 370 PPTLQPEYLQ 380 AAFPKPKWDC 390 QLFDSYSESL 400 PANQQPRDLN 410 RMEKTSVKDM 420 ADLPVPNQDV 430 TSDDKQALKS 440 TINEALPKDV 450 SEDPATPKDS 460 NSLKARPRSR 470 SYSSTSIEEA 480 MKRGEDPPTP 490 PPRPQKTHSR 500 ASSLDLNKVF 510 QPSVPATKSG 520 LLPPPPALPP 530 RPCPSQSEQV 540 SEAELLPQLS 550 RAPSQAAESS 560 PAKKDVLYSQ 570 PPSKPIRRKF 580 RPENQATENQ 590 EPSTAASGPA 600 SAATMKPHPT 610 VQKQSSKQKK 620 AIQTAIRKNK 630 EANAVLARLN 640 SELQQQLKEV 650 HQERIALENQ 660 LEQLRPVTVL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0016197	endosomal transport
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0065003	protein-containing complex assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.