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Overview

Uniprot ID	Q8NFJ5
Protein Name	Retinoic acid-induced protein 3
Gene Name	GPRC5A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
291	CKPQLVKKSYGVENR

Function

Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218)

Protein Sequence

10 MATTVPDGCR 20 NGLKSKYYRL 30 CDKAEAWGIV 40 LETVATAGVV 50 TSVAFMLTLP 60 ILVCKVQDSN 70 RRKMLPTQFL 80 FLLGVLGIFG 90 LTFAFIIGLD 100 GSTGPTRFFL 110 FGILFSICFS 120 CLLAHAVSLT 130 KLVRGRKPLS 140 LLVILGLAVG 150 FSLVQDVIAI 160 EYIVLTMNRT 170 NVNVFSELSA 180 PRRNEDFVLL 190 LTYVLFLMAL 200 TFLMSSFTFC 210 GSFTGWKRHG 220 AHIYLTMLLS 230 IAIWVAWITL 240 LMLPDFDRRW 250 DDTILSSALA 260 ANGWVFLLAY 270 VSPEFWLLTK 280 QRNPMDYPVE 290 DAFCKPQLVK 300 KSYGVENRAY 310 SQEEITQGFE 320 ETGDTLYAPY 330 STHFQLQNQP 340 PQKEFSIPRA 350 HAWPSPYKDY EVKKEGS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030659	cytoplasmic vesicle membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0043235	receptor complex
Cellular Component	GO:0031982	vesicle
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0004930	G protein-coupled receptor activity
Molecular Function	GO:0030295	protein kinase activator activity
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.