Overview
| Uniprot ID | Q8NFU3 |
|---|
| Protein Name | Thiosulfate:glutathione sulfurtransferase |
|---|
| Gene Name | TSTD1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 83 |
VFFCQMGKRGLQATQ |
Function
Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). GSS(-) spontaneously reacts with glutathione to form glutathione disulfide (Probable)
Protein Sequence
10
MAGAPTVSLP
20
ELRSLLASGR
30
ARLFDVRSRE
40
EAAAGTIPGA
50
LNIPVSELES
60
ALQMEPAAFQ
70
ALYSAEKPKL
80
EDEHLVFFCQ
90
MGKRGLQATQ
100
LARSLGYTGA
110
RNYAGAYREW
LEKES
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0050337 |
thiosulfate-thiol sulfurtransferase activity |
| Biological Process |
GO:0070221 |
sulfide oxidation, using sulfide:quinone oxidoreductase |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.