Search Results

Overview

Uniprot ID	Q8NFW8
Protein Name	N-acylneuraminate cytidylyltransferase
Gene Name	CMAS
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
185	FRWSEIQKGVREVTE
200	PLNLNPAKRPRRQDW
26	PSRGRPPKLQRNSRG

Function

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)

Protein Sequence

10 MDSVEKGAAT 20 SVSNPRGRPS 30 RGRPPKLQRN 40 SRGGQGRGVE 50 KPPHLAALIL 60 ARGGSKGIPL 70 KNIKHLAGVP 80 LIGWVLRAAL 90 DSGAFQSVWV 100 STDHDEIENV 110 AKQFGAQVHR 120 RSSEVSKDSS 130 TSLDAIIEFL 140 NYHNEVDIVG 150 NIQATSPCLH 160 PTDLQKVAEM 170 IREEGYDSVF 180 SVVRRHQFRW 190 SEIQKGVREV 200 TEPLNLNPAK 210 RPRRQDWDGE 220 LYENGSFYFA 230 KRHLIEMGYL 240 QGGKMAYYEM 250 RAEHSVDIDV 260 DIDWPIAEQR 270 VLRYGYFGKE 280 KLKEIKLLVC 290 NIDGCLTNGH 300 IYVSGDQKEI 310 ISYDVKDAIG 320 ISLLKKSGIE 330 VRLISERACS 340 KQTLSSLKLD 350 CKMEVSVSDK 360 LAVVDEWRKE 370 MGLCWKEVAY 380 LGNEVSDEEC 390 LKRVGLSGAP 400 ADACSTAQKA 410 VGYICKCNGG 420 RGAIREFAEH 430 ICLLMEKVNN SCQK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0008781	N-acylneuraminate cytidylyltransferase activity
Biological Process	GO:0006055	CMP-N-acetylneuraminate biosynthetic process
Biological Process	GO:0006054	N-acetylneuraminate metabolic process

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.